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Tchem
CAMK2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in res ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258682
  • ENSP00000258682
  • ENSG00000058404
  • ENST00000346990
  • ENSP00000326518
  • ENST00000347193
  • ENSP00000326544
  • ENST00000350811
  • ENSP00000326375
  • ENST00000353625
  • ENSP00000326427
  • ENST00000358707
  • ENSP00000351542
  • ENST00000395747
  • ENSP00000379096
  • ENST00000395749
  • ENSP00000379098
  • ENST00000440254
  • ENSP00000397937
  • ENST00000457475
  • ENSP00000390292

Symbol
  • CAM2
  • CAMK2
  • CAMKB
  • CAM2
  • CAMK2
  • CAMKB
  • MRD54
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
biological process
0.94
protein domain
0.92
PubMedID
0.88
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.41   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 484   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.41   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 484   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0