Tbio CALML3 Calmodulin-like protein 3

Protein Summary

Description

May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.

Uniprot Accession IDs

• P27482
• B2R9V6
• Q5SQI4

Gene Name

• CALML3

Ensembl ID

• ENST00000315238
• ENSP00000315299
• ENSG00000178363

Symbol

• CLP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.57
gene perturbation	0.57
pathway	0.56
cell type or tissue	0.55
protein complex	0.5

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calmodulin-like Protein 3

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calmodulin-like Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.14   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.14   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0