Protein Summary
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
- ENST00000356978
- ENSP00000349467
- ENSG00000198668
- CALM
- CAM
- CAM1
- caM
- CAM2
- CAM3
- CAMB
- CAMC
- CAMI
- PHKD
- CPVT4
- DD132
- LQT14
- CALML2
- CAMIII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 1 | ||
hub protein | 0.97 | ||
pathway | 0.97 | ||
transcription factor perturbation | 0.91 | ||
transcription factor binding site profile | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 324.03 (req: < 5)
Gene RIFs: 161 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 324.03 (req: >= 5)
Gene RIFs: 161 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 57
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (4)
Protein-Protein Interactions (443)
Nearest Tclin Targets
Pathways (192)
Reactome (129)
KEGG (40)
PathwayCommons (5)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of AMPK downstream of NMDARs | ||||
Reactome | Activation of Ca-permeable Kainate Receptor | ||||
Reactome | Activation of NMDA receptors and postsynaptic events | ||||
Reactome | Activation of RAC1 downstream of NMDARs | ||||
Reactome | Activation of kainate receptors upon glutamate binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of AMPK downstream of NMDARs | ||||
Activation of Ca-permeable Kainate Receptor | ||||
Activation of NMDA receptors and postsynaptic events | ||||
Activation of RAC1 downstream of NMDARs | ||||
Activation of kainate receptors upon glutamate binding | ||||
Viral Interactions (0)
Gene Ontology Terms (75)
Functions (19)
Components (18)
Processes (38)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
longevity | 1 | 1 | 0 | 5 | 33.1 | ||||
gut microbiome measurement | 1 | 1 | 1 | 0.4 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
longevity | 0 | 5 | 33.1 | ||||
gut microbiome measurement | 1 | 0.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:88251 | 12313 | ||||||
Rat | RGD:2257 | 24242 | ||||||
Dog | calmodulin 2 | 474584 | ||||||
Horse | calmodulin 2 | 100629145 | ||||||
Cow | calmodulin-like | 326597 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | calmodulin 2 | |||||
Horse | calmodulin 2 | |||||
Cow | calmodulin-like | |||||
Publication Statistics
PubMed Score 324.03
PubMed score by year
PubTator Score 4282.05
PubTator score by year
Related Publications
Text Mined References (343)
GeneRif Annotations (161)
Items per page:
0 of 0
PMID | Year | Title |
|---|