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Tdark
CALHM4
Calcium homeostasis modulator protein 4

Protein Summary
Description
Pore-forming subunit of a voltage-gated ion channel.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368596
  • ENSP00000357585
  • ENSG00000164451
  • ENST00000368597
  • ENSP00000357586
  • ENST00000405399
  • ENSP00000385836
  • ENST00000628083
  • ENSP00000487169

Symbol
  • C6orf78
  • FAM26D
  • FAM26D
  • C6orf78
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.36   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.36   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.999989788
p_ni:  0.000010206
p_wrong:  6e-9
Data Source:  BioPlex
FBXO3
Tbio
Novelty:  0.01701102
p_int:  0.999989253
p_ni:  0.000010448
p_wrong:  2.99e-7
Data Source:  BioPlex
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.999949447
p_ni:  0.000050551
p_wrong:  1e-9
Data Source:  BioPlex
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.999909695
p_ni:  0.000079385
p_wrong:  0.00001092
Data Source:  BioPlex
ZMAT4
Tdark
Novelty:  0.31281969
p_int:  0.999610557
p_ni:  0.000389247
p_wrong:  1.97e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.999450863
p_ni:  0.000233265
p_wrong:  0.000315872
Data Source:  BioPlex
SEMG2
Tbio
Novelty:  0.06325799
p_int:  0.999411944
p_ni:  0.00058793
p_wrong:  1.26e-7
Data Source:  BioPlex
PYHIN1
Tbio
Novelty:  0.06662677
p_int:  0.999158103
p_ni:  0.000841809
p_wrong:  8.9e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
TEX35
Tdark
Novelty:  0.5605055
p_int:  0.998742578
p_ni:  0.001257326
p_wrong:  9.6e-8
Score:  0.191
Data Source:  BioPlex,STRINGDB
PTPN9
Tchem
Family:  Enzyme
Novelty:  0.01574113
p_int:  0.998602119
p_ni:  0.001397831
p_wrong:  5e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2
27.9
1
1
0
1.1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
27.9
0
1.1
7.9
IDG Resources
Cell
image for
Details:
  • Species:  Homo sapiens
Publication Statistics
PubMed Score 0.36
PubMed score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title