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Tbio
CALCOCO2
Calcium-binding and coiled-coil domain-containing protein 2

Protein Summary
Description
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). This gene encodes a coiled-coil domain-containing protein. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258947
  • ENSP00000258947
  • ENSG00000136436
  • ENST00000416445
  • ENSP00000406974
  • ENST00000448105
  • ENSP00000398523
  • ENST00000508679
  • ENSP00000423437
  • ENST00000509507
  • ENSP00000424352

Symbol
  • NDP52
  • NDP52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
interacting protein
0.95
PubMedID
0.73
tissue
0.68
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.21   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.21   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (145)
AZI2
Tbio
Novelty:  0.23255317
p_int:  0.999998792
p_ni:  3.2e-8
p_wrong:  0.000001176
Score:  0.706
Data Source:  BioPlex,STRINGDB
INAVA
Tbio
Novelty:  0.19311978
p_int:  0.99999833
p_ni:  0.00000167
Data Source:  BioPlex
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
p_int:  0.999991201
p_ni:  0.000008799
Score:  0.986
Data Source:  BioPlex,STRINGDB
TBKBP1
Tbio
Family:  Enzyme
Novelty:  0.11778482
p_int:  0.999985167
p_ni:  0.000012386
p_wrong:  0.000002447
Score:  0.919
Data Source:  BioPlex,STRINGDB
MTPAP
Tbio
Family:  Enzyme
Novelty:  0.03447508
p_int:  0.999972864
p_ni:  0.000027136
Score:  0.514
Data Source:  BioPlex,STRINGDB
TCL1A
Tbio
Novelty:  0.00606987
p_int:  0.99994422
p_ni:  0.00005578
Data Source:  BioPlex
CHRDL1
Tbio
Novelty:  0.01748654
p_int:  0.999931743
p_ni:  0.000068257
Score:  0.189
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999693299
p_ni:  0.000306701
Score:  0.976
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.998435666
p_ni:  0.001564334
Data Source:  BioPlex
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.997595354
p_ni:  0.002404641
p_wrong:  5e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
2
6.6
80
body height
2
2
2
78.7
5
5
1
1.1
77.9
BMI-adjusted hip circumference
2
3
3
64.3
platelet crit
1
1
1
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
6.6
80
body height
2
78.7
1
1.1
77.9
BMI-adjusted hip circumference
3
64.3
platelet crit
1
64
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium binding and coiled-coil domain 2
VGNC:9165
455194
Macaque
calcium binding and coiled-coil domain 2
697836
Mouse
MGI:1343177
76815
Dog
calcium binding and coiled-coil domain 2
VGNC:38663
480545
Horse
calcium binding and coiled-coil domain 2
VGNC:16006
100055791
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium binding and coiled-coil domain 2
Macaque
calcium binding and coiled-coil domain 2
Mouse
Dog
calcium binding and coiled-coil domain 2
Horse
calcium binding and coiled-coil domain 2
Publication Statistics
PubMed Score 78.21
PubMed score by year
PubTator Score 30.62
PubTator score by year
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Related Publications
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PMID
Year
Title