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Tbio
CALCOCO1
Calcium-binding and coiled-coil domain-containing protein 1

Protein Summary
Description
Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262059
  • ENSP00000262059
  • ENSG00000012822
  • ENST00000430117
  • ENSP00000397189
  • ENST00000548263
  • ENSP00000447647
  • ENST00000550804
  • ENSP00000449960

Symbol
  • KIAA1536
  • Cocoa
  • PP13275
  • calphoglin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
transcription factor binding site profile
0.72
virus perturbation
0.72
histone modification site profile
0.71
transcription factor
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.62   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.62   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999999951
p_ni:  4.9e-8
Data Source:  BioPlex
MAFF
Tbio
Family:  TF
Novelty:  0.01974936
p_int:  0.9999942
p_ni:  0.0000058
Score:  0.173
Data Source:  BioPlex,STRINGDB
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.999993418
p_ni:  0.000006582
Data Source:  BioPlex
BFSP2
Tbio
Novelty:  0.00206411
p_int:  0.999965477
p_ni:  0.000034523
Score:  0.173
Data Source:  BioPlex,STRINGDB
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999942511
p_ni:  0.000057489
Data Source:  BioPlex
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.9999373
p_ni:  0.0000627
Data Source:  BioPlex
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.999916799
p_ni:  0.000083201
Data Source:  BioPlex
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.99986938
p_ni:  0.00013062
Data Source:  BioPlex
TXLNB
Tbio
Novelty:  0.12751933
p_int:  0.999452497
p_ni:  0.000547503
Score:  0.167
Data Source:  BioPlex,STRINGDB
FOSL2
Tbio
Family:  TF
Novelty:  0.00375452
p_int:  0.994382668
p_ni:  0.005617316
p_wrong:  1.6e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
AgBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
AgBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
89.6
body height
2
3
3
87.6
monocyte percentage of leukocytes
1
2
2
85.7
neutrophil percentage of leukocytes
1
1
1
74.8
myeloid white cell count
1
1
1
59.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
89.6
body height
3
87.6
monocyte percentage of leukocytes
2
85.7
neutrophil percentage of leukocytes
1
74.8
myeloid white cell count
1
59.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium binding and coiled-coil domain 1
VGNC:5314
451944
Macaque
calcium binding and coiled-coil domain 1
703855
Mouse
MGI:1914738
67488
Rat
RGD:619812
246047
Dog
calcium binding and coiled-coil domain 1
VGNC:38662
486505
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium binding and coiled-coil domain 1
Macaque
calcium binding and coiled-coil domain 1
Mouse
Rat
Dog
calcium binding and coiled-coil domain 1
Publication Statistics
PubMed Score 8.62
PubMed score by year
PubTator Score 2.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title