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Tclin
CALCB
Calcitonin gene-related peptide 2

Protein Summary
Description
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324229
  • ENSP00000346017
  • ENSG00000175868
  • ENST00000533448
  • ENSP00000433490

Symbol
  • CALC2
  • CALC2
  • CGRP2
  • CGRP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.73
disease perturbation
0.62
tissue
0.58
histone modification site profile
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.45   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.45   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
GIP
Tbio
Novelty:  0.0007219
p_int:  0.997104137
p_ni:  8.67e-7
p_wrong:  0.002894996
Score:  0.9
Data Source:  BioPlex,STRINGDB
P06881
Tclin
Novelty:  0.00010496
p_int:  0.959087989
p_ni:  8e-9
p_wrong:  0.040912003
Score:  0.909
Data Source:  BioPlex,STRINGDB
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.908660843
p_ni:  2.23e-7
p_wrong:  0.091338934
Score:  0.221
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.855098813
p_ni:  0.000529932
p_wrong:  0.144371255
Data Source:  BioPlex
IAPP
Tbio
Novelty:  0.0005195
Score:  0.982
Data Source:  STRINGDB
ADM
Tbio
Novelty:  0.0004958
Score:  0.974
Data Source:  STRINGDB
RAMP1
Tclin
Novelty:  0.00831253
Score:  0.974
Data Source:  Reactome,STRINGDB
RAMP2
Tclin
Novelty:  0.01086538
Score:  0.974
Data Source:  STRINGDB
CALCR
Tclin
Family:  GPCR
Novelty:  0.00112487
Score:  0.97
Data Source:  STRINGDB
CALCRL
Tclin
Family:  GPCR
Novelty:  0.00568602
Score:  0.97
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Calcitonin-like ligand receptors (R-HSA-419812)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
14
22
32
6.3
99.9
high density lipoprotein cholesterol measurement
4
2
4
88.2
seasonality measurement
1
1
0
21.1
87.2
heel bone mineral density
3
1
5
86.9
vitamin D deficiency
1
1
1
80.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
32
6.3
99.9
high density lipoprotein cholesterol measurement
4
88.2
seasonality measurement
0
21.1
87.2
heel bone mineral density
5
86.9
vitamin D deficiency
1
80.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcitonin related polypeptide beta
VGNC:7798
451044
Macaque
calcitonin gene-related peptide 2
698209
Mouse
MGI:2151254
116903
Rat
RGD:620997
171519
Dog
calcitonin-related polypeptide beta
403415
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcitonin related polypeptide beta
Macaque
calcitonin gene-related peptide 2
Mouse
Rat
Dog
calcitonin-related polypeptide beta
Publication Statistics
PubMed Score 44.45
PubMed score by year
PubTator Score 59.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title