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Tbio
CADM4
Cell adhesion molecule 4

Protein Summary
Description
Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222374
  • ENSP00000222374
  • ENSG00000105767

Symbol
  • IGSF4C
  • NECL4
  • TSLL2
  • NECL4
  • TSLL2
  • IGSF4C
  • Necl-4
  • synCAM4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
protein domain
0.97
histone modification site profile
0.71
tissue sample
0.65
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.39   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.39   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.999268682
p_ni:  0.000731228
p_wrong:  9e-8
Data Source:  BioPlex
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.998999752
p_ni:  0.000984167
p_wrong:  0.000016081
Data Source:  BioPlex
MTRF1
Tbio
Family:  Enzyme
Novelty:  0.11037387
p_int:  0.998644406
p_ni:  0.001355082
p_wrong:  5.12e-7
Data Source:  BioPlex
NR2F6
Tbio
Family:  NR
Novelty:  0.02314124
p_int:  0.993154573
p_ni:  0.006614573
p_wrong:  0.000230854
Data Source:  BioPlex
SCPEP1
Tbio
Family:  Enzyme
Novelty:  0.08603794
p_int:  0.939923893
p_ni:  0.043357731
p_wrong:  0.016718376
Data Source:  BioPlex
FARSB
Tchem
Family:  Enzyme
Novelty:  0.09683467
p_int:  0.935530253
p_ni:  0.03738418
p_wrong:  0.027085567
Data Source:  BioPlex
HEPACAM2
Tbio
Novelty:  0.19192547
p_int:  0.91175748
p_ni:  0.000059187
p_wrong:  0.088183333
Score:  0.229
Data Source:  BioPlex,STRINGDB
EPHB6
Tchem
Family:  Kinase
Novelty:  0.02310045
p_int:  0.823694965
p_ni:  0.004567262
p_wrong:  0.171737773
Data Source:  BioPlex
CD69
Tchem
Novelty:  0.00056432
p_int:  0.791109841
p_ni:  0.000067039
p_wrong:  0.20882312
Score:  0.416
Data Source:  BioPlex,STRINGDB
IL20
Tbio
Novelty:  0.78184288
p_int:  0.786085162
p_ni:  0.113812132
p_wrong:  0.100102706
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urokinase plasminogen activator surface receptor measurement
2
5
5
99.4
TNF-related apoptosis-inducing ligand measurement
2
1
2
89.9
apolipoprotein B measurement
2
3
3
83.2
neutrophil count
4
1
4
78.3
myeloid white cell count
2
1
2
78.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urokinase plasminogen activator surface receptor measurement
5
99.4
TNF-related apoptosis-inducing ligand measurement
2
89.9
apolipoprotein B measurement
3
83.2
neutrophil count
4
78.3
myeloid white cell count
2
78.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell adhesion molecule 4
VGNC:2376
456096
Macaque
cell adhesion molecule 4
711775
Mouse
MGI:2449088
260299
Rat
RGD:1304722
365216
Dog
cell adhesion molecule 4
VGNC:53675
484465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell adhesion molecule 4
Macaque
cell adhesion molecule 4
Mouse
Rat
Dog
cell adhesion molecule 4
Publication Statistics
PubMed Score 27.39
PubMed score by year
PubTator Score 14.31
PubTator score by year
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Related Publications
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PMID
Year
Title