CACYBP
Calcyclin-binding protein
Protein Summary
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000367679
- ENSP00000356652
- ENSG00000116161
- ENST00000405362
- ENSP00000385771
- ENST00000406752
- ENSP00000384139
- ENST00000613570
- ENSP00000479414
- S100A6BP
- SIP
- SIP
- GIG5
- PNAS-107
- S100A6BP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
transcription factor perturbation | 0.99 | ||
transcription factor binding site profile | 0.98 | ||
kinase perturbation | 0.97 | ||
disease perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.66 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 339 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.66 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 339 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0