Tdark CACNG7 Voltage-dependent calcium channel gamma-7 subunit

Protein Summary

Description

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2 (PubMed:21172611). The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• P62955
• Q52LL8
• Q8VBX3
• Q8WXS6
• Q9BXT1

Gene Name

• CACNG7

Ensembl ID

• ENST00000222212
• ENSP00000222212
• ENSG00000105605
• ENST00000391767
• ENSP00000375647

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
gene perturbation	0.68
cell type or tissue	0.65
cell line	0.51
metabolite	0.45

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Auxiliary Subunit 1-8 (Cca) Family / Voltage-dependent Calcium Channel Gamma-7 Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.72   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.72   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0