CACNB3
Voltage-dependent L-type calcium channel subunit beta-3
Protein Summary
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
- ENST00000301050
- ENSP00000301050
- ENSG00000167535
- ENST00000536187
- ENSP00000444160
- ENST00000540990
- ENSP00000445495
- ENST00000547230
- ENSP00000448304
- CACNLB3
- CAB3
- CACNLB3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.9 | ||
hub protein | 0.88 | ||
disease perturbation | 0.87 | ||
PubMedID | 0.81 | ||
transcription factor binding site profile | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.72 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 190 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.72 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 190 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0