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Tbio
CACNB2
Voltage-dependent L-type calcium channel subunit beta-2

Protein Summary
Description
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282343
  • ENSP00000282343
  • ENSG00000165995
  • ENST00000324631
  • ENSP00000320025
  • ENST00000352115
  • ENSP00000344474
  • ENST00000377315
  • ENSP00000366532
  • ENST00000377319
  • ENSP00000366536
  • ENST00000377329
  • ENSP00000366546
  • ENST00000396576
  • ENSP00000379821
  • ENST00000645287
  • ENSP00000496203

Symbol
  • CACNLB2
  • MYSB
  • MYSB
  • CAVB2
  • CACNLB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
kinase perturbation
0.95
molecular function
0.84
transcription factor
0.82
PubMedID
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.85   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 548   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.85   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
CACNB1
Tbio
Family:  IC
Novelty:  0.06568749
p_int:  0.999999981
p_ni:  1e-9
p_wrong:  1.8e-8
Score:  0.959
Data Source:  BioPlex,STRINGDB
CACNB3
Tbio
Family:  IC
Novelty:  0.04007679
p_int:  0.999999974
p_wrong:  2.6e-8
Score:  0.952
Data Source:  BioPlex,STRINGDB
CACNA1C
Tclin
Family:  IC
Novelty:  0.00099998
Score:  0.997
Data Source:  Reactome,STRINGDB
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
Score:  0.995
Data Source:  Reactome,STRINGDB
CACNA1D
Tclin
Family:  IC
Novelty:  0.00314752
Score:  0.991
Data Source:  Reactome,STRINGDB
CACNA1S
Tclin
Family:  IC
Novelty:  0.00434282
Score:  0.989
Data Source:  Reactome,STRINGDB
CACNA1F
Tchem
Family:  IC
Novelty:  0.00431963
Score:  0.986
Data Source:  Reactome,STRINGDB
CACNA2D2
Tclin
Family:  IC
Novelty:  0.02041017
Score:  0.986
Data Source:  Reactome,STRINGDB
CACNA1A
Tchem
Family:  IC
Novelty:  0.00069217
Score:  0.978
Data Source:  STRINGDB
CACNA2D4
Tbio
Family:  IC
Novelty:  0.02238343
Score:  0.973
Data Source:  Reactome,STRINGDB
Pathways (30)
Adrenaline,noradrenaline inhibits insulin secretion (R-HSA-400042)

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Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Integration of energy metabolism
Name
Explore in Pharos
Explore in Source
Adrenaline,noradrenaline inhibits insulin secretion
Axon guidance
Cardiac conduction
Developmental Biology
Integration of energy metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
4
4
4
87.3
5
5
1
1.1
80
Agents acting on the renin-angiotensin system use measurement
1
2
2
75
1
1
1
74.2
blood pressure
1
1
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
4
87.3
1
1.1
80
Agents acting on the renin-angiotensin system use measurement
2
75
1
74.2
blood pressure
1
66.8
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit beta 2
VGNC:7842
740138
Macaque
calcium voltage-gated channel auxiliary subunit beta 2
701226
Mouse
MGI:894644
12296
Rat
RGD:67385
116600
Dog
calcium voltage-gated channel auxiliary subunit beta 2
VGNC:38645
487113
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit beta 2
Macaque
calcium voltage-gated channel auxiliary subunit beta 2
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit beta 2
Publication Statistics
PubMed Score 52.85
PubMed score by year
PubTator Score 37.45
PubTator score by year
Patents
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Related Publications
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PMID
Year
Title