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Tbio
CACNB2
Voltage-dependent L-type calcium channel subunit beta-2

Protein Summary
Description
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282343
  • ENSP00000282343
  • ENSG00000165995
  • ENST00000324631
  • ENSP00000320025
  • ENST00000352115
  • ENSP00000344474
  • ENST00000377315
  • ENSP00000366532
  • ENST00000377319
  • ENSP00000366536
  • ENST00000377329
  • ENSP00000366546
  • ENST00000396576
  • ENSP00000379821
  • ENST00000645287
  • ENSP00000496203

Symbol
  • CACNLB2
  • MYSB
  • MYSB
  • CAVB2
  • CACNLB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
kinase perturbation
0.95
molecular function
0.84
transcription factor
0.82
PubMedID
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.97   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 548   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.97   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0