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Tbio
CACNB1
Voltage-dependent L-type calcium channel subunit beta-1

Protein Summary
Description
Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344140
  • ENSP00000345461
  • ENSG00000067191
  • ENST00000394303
  • ENSP00000377840
  • ENST00000394310
  • ENSP00000377847

Symbol
  • CACNLB1
  • CAB1
  • CCHLB1
  • CACNLB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
molecular function
0.79
co-expressed gene
0.76
virus perturbation
0.76
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.03   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 370   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.03   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
CACNB2
Tbio
Family:  IC
Novelty:  0.01745218
p_int:  0.999999981
p_ni:  1e-9
p_wrong:  1.8e-8
Score:  0.959
Data Source:  BioPlex,STRINGDB
CACNB3
Tbio
Family:  IC
Novelty:  0.04007679
p_int:  0.999999897
p_ni:  1.03e-7
Score:  0.93
Data Source:  BioPlex,STRINGDB
CBARP
Tbio
Novelty:  0.04783435
p_int:  0.999961336
p_ni:  0.000038664
Score:  0.823
Data Source:  BioPlex,STRINGDB
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.998815913
p_ni:  0.001184083
p_wrong:  5e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
WDR75
Tbio
Novelty:  0.09443914
p_int:  0.758537765
p_ni:  0.241210508
p_wrong:  0.000251727
Score:  0.241
Data Source:  BioPlex,STRINGDB
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
Score:  0.998
Data Source:  Reactome,STRINGDB
CACNG1
Tbio
Family:  IC
Novelty:  0.11899252
Score:  0.997
Data Source:  STRINGDB
CACNA1D
Tclin
Family:  IC
Novelty:  0.00314752
Score:  0.995
Data Source:  Reactome,STRINGDB
CACNA1C
Tclin
Family:  IC
Novelty:  0.00099998
Score:  0.992
Data Source:  Reactome,STRINGDB
CACNA1S
Tclin
Family:  IC
Novelty:  0.00434282
Score:  0.99
Data Source:  Reactome,STRINGDB
Pathways (26)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Muscle contraction
Reactome
NCAM signaling for neurite out-growth
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Muscle contraction
NCAM signaling for neurite out-growth
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
3
2
13
92.1
mean corpuscular volume
1
1
1
81.2
reticulocyte measurement
2
1
2
68.6
creatinine measurement
1
2
2
50.5
1
1
0
1.1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
13
92.1
mean corpuscular volume
1
81.2
reticulocyte measurement
2
68.6
creatinine measurement
2
50.5
0
1.1
40.7
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit beta 1
VGNC:9143
454624
Macaque
calcium voltage-gated channel auxiliary subunit beta 1
695864
Mouse
MGI:102522
12295
Rat
RGD:68382
50688
Dog
calcium voltage-gated channel auxiliary subunit beta 1
VGNC:38644
491030
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit beta 1
Macaque
calcium voltage-gated channel auxiliary subunit beta 1
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit beta 1
Publication Statistics
PubMed Score 12.03
PubMed score by year
PubTator Score 6.18
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title