Tbio CACNA2D4 Voltage-dependent calcium channel subunit alpha-2/delta-4

Protein Summary

Description

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q7Z3S7
• Q7Z3S8
• Q86XZ5
• Q8IZS9

Gene Name

• CACNA2D4

Ensembl ID

• ENST00000382722
• ENSP00000372169
• ENSG00000151062
• ENST00000545595
• ENSP00000442329
• ENST00000585708
• ENSP00000467697
• ENST00000586184
• ENSP00000465060
• ENST00000588077
• ENSP00000468530
• ENST00000642910
• ENSP00000494565
• ENSG00000284953
• ENST00000644981
• ENSP00000494395
• ENST00000645018
• ENSP00000495256
• ENST00000645225
• ENSP00000493490
• ENST00000646498
• ENSP00000494913

Symbol

• RCD4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
molecular function	0.91
cell line	0.67
disease	0.55
tissue sample	0.54

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Auxiliary Subunit 2 Types 1-4 (Cca-2) Family / Voltage-dependent Calcium Channel Subunit Alpha-2/delta-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.07   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.07   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0