Tclin CACNA2D2 Voltage-dependent calcium channel subunit alpha-2/delta-2

Protein Summary

Description

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q9NY47
• A7MD15
• Q9NY48
• Q9UEW0
• Q9Y268

Gene Name

• CACNA2D2

Ensembl ID

• ENST00000266039
• ENSP00000266039
• ENSG00000007402
• ENST00000360963
• ENSP00000354228
• ENST00000424201
• ENSP00000390329
• ENST00000479441
• ENSP00000418081

Symbol

• KIAA0558
• CACNA2D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
PubMedID	0.79
tissue sample	0.72
microRNA	0.65
transcription factor perturbation	0.61

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Auxiliary Subunit 2 Types 1-4 (Cca-2) Family / Voltage-dependent Calcium Channel Subunit Alpha-2/delta-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.75   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.75   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3