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Tclin
CACNA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

Protein Summary
Description
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356253
  • ENSP00000348589
  • ENSG00000153956
  • ENST00000356860
  • ENSP00000349320

Symbol
  • CACNL2A
  • CCHL2A
  • MHS3
  • CACNA2
  • CCHL2A
  • CACNL2A
  • LINC01112
  • lncRNA-N3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
molecular function
0.91
transcription factor perturbation
0.91
PubMedID
0.8
co-expressed gene
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.16   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.16   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 210
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4