Tclin CACNA1I Voltage-dependent T-type calcium channel subunit alpha-1I

Protein Summary

Description

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity). This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q9P0X4
• B0QY12
• B0QY13
• B0QY14
• O95504
• Q5JZ88
• Q7Z6S9
• Q8NFX6
• Q9NZC8
• Q9UH15
• Q9UH30
• Q9ULU9
• Q9UNE6

Gene Name

• CACNA1I

Ensembl ID

• ENST00000401624
• ENSP00000383887
• ENSG00000100346
• ENST00000402142
• ENSP00000385019
• ENST00000404898
• ENSP00000384093
• ENST00000407673
• ENSP00000385680

Symbol

• KIAA1120
• Cav3.3
• ca(v)3.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.84
protein domain	0.73
virus perturbation	0.64
small molecule perturbation	0.61
tissue	0.56

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Sodium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1i

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Calcium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1i

Protein / Transporter / Ion Channel / Sodium Channel / Voltage-gated Sodium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1i

Protein / Transporter / Ion Channel / Calcium Channel / Voltage-gated Calcium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1i

DTO Classes

Protein / Ion Channel / Calcium Channel Alpha-1 Subunit Family / Cacna1i Subfamily / Voltage-dependent T-type Calcium Channel Subunit Alpha-1i

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.17   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.17   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 250

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6