You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CACNA1H
Voltage-dependent T-type calcium channel subunit alpha-1H

Protein Summary
Description
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348261
  • ENSP00000334198
  • ENSG00000196557
  • ENST00000358590
  • ENSP00000351401
  • ENST00000565831
  • ENSP00000455840

Symbol
  • ECA6
  • EIG6
  • HALD4
  • Cav3.2
  • CACNA1HB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
biological process
0.85
small molecule perturbation
0.68
PubMedID
0.67
transcription factor
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391.4   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391.4   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 390
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7