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Tclin
CACNA1G
Voltage-dependent T-type calcium channel subunit alpha-1G

Protein Classes
Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352832
  • ENSP00000339302
  • ENSG00000006283
  • ENST00000354983
  • ENSP00000347078
  • ENST00000358244
  • ENSP00000350979
  • ENST00000359106
  • ENSP00000352011
  • ENST00000360761
  • ENSP00000353990
  • ENST00000429973
  • ENSP00000414388
  • ENST00000442258
  • ENSP00000409759
  • ENST00000502264
  • ENSP00000425522
  • ENST00000503436
  • ENSP00000427231
  • ENST00000503485
  • ENSP00000427238
  • ENST00000503607
  • ENSP00000426558
  • ENST00000504076
  • ENSP00000425153
  • ENST00000505165
  • ENSP00000422268
  • ENST00000506406
  • ENSP00000426313
  • ENST00000507336
  • ENSP00000420918
  • ENST00000507510
  • ENSP00000423112
  • ENST00000507609
  • ENSP00000423045
  • ENST00000507896
  • ENSP00000421518
  • ENST00000510115
  • ENSP00000427173
  • ENST00000510366
  • ENSP00000426814
  • ENST00000511765
  • ENSP00000427247
  • ENST00000511768
  • ENSP00000424664
  • ENST00000512389
  • ENSP00000426261
  • ENST00000513689
  • ENSP00000426172
  • ENST00000513964
  • ENSP00000425451
  • ENST00000514079
  • ENSP00000423317
  • ENST00000514181
  • ENSP00000425698
  • ENST00000514717
  • ENSP00000422407
  • ENST00000515165
  • ENSP00000426098
  • ENST00000515411
  • ENSP00000423155
  • ENST00000515765
  • ENSP00000426232

Symbol
  • KIAA1123
  • NBR13
  • SCA42
  • Cav3.1
  • SCA42ND
  • Ca(V)T.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
molecular function
0.86
transcription factor
0.83
PubMedID
0.76
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.74   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.74   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 331
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
41.5
electrocardiography
1
1
4
15.5
risk-taking behaviour
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
41.5
electrocardiography
4
15.5
risk-taking behaviour
1
8.1
Pathways (18)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
NCAM signaling for neurite out-growth
Reactome
NCAM1 interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
NCAM signaling for neurite out-growth
NCAM1 interactions
Gene Ontology Terms (25)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (121)
1 – 10 of 121
NCAM1
Tbio
Novelty: 0.00020994
Score: 0.909
Data Source: Reactome,STRINGDB
CACNA1I
Tclin
Family: IC
Novelty: 0.00802209
Score: 0.824
Data Source: STRINGDB
CACNB1
Tbio
Family: IC
Novelty: 0.06568749
Score: 0.822
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.822
Data Source: STRINGDB
CALML4
Tdark
Novelty: 0.44764047
Score: 0.818
Data Source: STRINGDB
NOS1
Tchem
Family: Enzyme
Novelty: 0.00032064
Score: 0.816
Data Source: STRINGDB
CACNA1H
Tclin
Family: IC
Novelty: 0.00342394
Score: 0.814
Data Source: STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
Score: 0.811
Data Source: STRINGDB
CAV3
Tbio
Novelty: 0.00190092
Score: 0.811
Data Source: STRINGDB
GNB2
Tbio
Novelty: 0.08682553
Score: 0.806
Data Source: STRINGDB
Publication Statistics
PubMed Score  259.74

PubMed score by year
PubTator Score  141.32

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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