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Tclin
CACNA1G
Voltage-dependent T-type calcium channel subunit alpha-1G

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352832
  • ENSP00000339302
  • ENSG00000006283
  • ENST00000354983
  • ENSP00000347078
  • ENST00000358244
  • ENSP00000350979
  • ENST00000359106
  • ENSP00000352011
  • ENST00000360761
  • ENSP00000353990
  • ENST00000429973
  • ENSP00000414388
  • ENST00000442258
  • ENSP00000409759
  • ENST00000502264
  • ENSP00000425522
  • ENST00000503436
  • ENSP00000427231
  • ENST00000503485
  • ENSP00000427238
  • ENST00000503607
  • ENSP00000426558
  • ENST00000504076
  • ENSP00000425153
  • ENST00000505165
  • ENSP00000422268
  • ENST00000506406
  • ENSP00000426313
  • ENST00000507336
  • ENSP00000420918
  • ENST00000507510
  • ENSP00000423112
  • ENST00000507609
  • ENSP00000423045
  • ENST00000507896
  • ENSP00000421518
  • ENST00000510115
  • ENSP00000427173
  • ENST00000510366
  • ENSP00000426814
  • ENST00000511765
  • ENSP00000427247
  • ENST00000511768
  • ENSP00000424664
  • ENST00000512389
  • ENSP00000426261
  • ENST00000513689
  • ENSP00000426172
  • ENST00000513964
  • ENSP00000425451
  • ENST00000514079
  • ENSP00000423317
  • ENST00000514181
  • ENSP00000425698
  • ENST00000514717
  • ENSP00000422407
  • ENST00000515165
  • ENSP00000426098
  • ENST00000515411
  • ENSP00000423155
  • ENST00000515765
  • ENSP00000426232

Symbol
  • KIAA1123
  • NBR13
  • SCA42
  • Cav3.1
  • SCA42ND
  • Ca(V)T.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
molecular function
0.86
transcription factor
0.83
PubMedID
0.76
protein domain
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.54   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.54   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 510
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (121)
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.909
Data Source:  Reactome,STRINGDB
CACNA1I
Tclin
Family:  IC
Novelty:  0.00802209
Score:  0.824
Data Source:  STRINGDB
CACNB1
Tbio
Family:  IC
Novelty:  0.06568749
Score:  0.822
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.822
Data Source:  STRINGDB
CALML4
Tdark
Novelty:  0.44764047
Score:  0.818
Data Source:  STRINGDB
NOS1
Tchem
Family:  Enzyme
Novelty:  0.00032064
Score:  0.816
Data Source:  STRINGDB
CACNA1H
Tclin
Family:  IC
Novelty:  0.00342394
Score:  0.814
Data Source:  STRINGDB
CACNB3
Tbio
Family:  IC
Novelty:  0.04007679
Score:  0.811
Data Source:  STRINGDB
CAV3
Tbio
Novelty:  0.00190092
Score:  0.811
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.806
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
NCAM signaling for neurite out-growth
Reactome
NCAM1 interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
NCAM signaling for neurite out-growth
NCAM1 interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
77.1
risk-taking behaviour
1
2
2
54.2
reticulocyte count
2
2
2
52.3
hip circumference
1
2
2
47.5
sex hormone-binding globulin measurement
2
1
2
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
77.1
risk-taking behaviour
2
54.2
reticulocyte count
2
52.3
hip circumference
2
47.5
sex hormone-binding globulin measurement
2
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 G
VGNC:12033
455128
Macaque
calcium voltage-gated channel subunit alpha1 G
706230
Mouse
MGI:1201678
12291
Rat
RGD:68942
29717
Dog
calcium voltage-gated channel subunit alpha1 G
VGNC:38637
491083
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 G
Macaque
calcium voltage-gated channel subunit alpha1 G
Mouse
Rat
Dog
calcium voltage-gated channel subunit alpha1 G
Publication Statistics
PubMed Score 268.54
PubMed score by year
PubTator Score 141.32
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title