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Tclin
CACNA1G
Voltage-dependent T-type calcium channel subunit alpha-1G

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352832
  • ENSP00000339302
  • ENSG00000006283
  • ENST00000354983
  • ENSP00000347078
  • ENST00000358244
  • ENSP00000350979
  • ENST00000359106
  • ENSP00000352011
  • ENST00000360761
  • ENSP00000353990
  • ENST00000429973
  • ENSP00000414388
  • ENST00000442258
  • ENSP00000409759
  • ENST00000502264
  • ENSP00000425522
  • ENST00000503436
  • ENSP00000427231
  • ENST00000503485
  • ENSP00000427238
  • ENST00000503607
  • ENSP00000426558
  • ENST00000504076
  • ENSP00000425153
  • ENST00000505165
  • ENSP00000422268
  • ENST00000506406
  • ENSP00000426313
  • ENST00000507336
  • ENSP00000420918
  • ENST00000507510
  • ENSP00000423112
  • ENST00000507609
  • ENSP00000423045
  • ENST00000507896
  • ENSP00000421518
  • ENST00000510115
  • ENSP00000427173
  • ENST00000510366
  • ENSP00000426814
  • ENST00000511765
  • ENSP00000427247
  • ENST00000511768
  • ENSP00000424664
  • ENST00000512389
  • ENSP00000426261
  • ENST00000513689
  • ENSP00000426172
  • ENST00000513964
  • ENSP00000425451
  • ENST00000514079
  • ENSP00000423317
  • ENST00000514181
  • ENSP00000425698
  • ENST00000514717
  • ENSP00000422407
  • ENST00000515165
  • ENSP00000426098
  • ENST00000515411
  • ENSP00000423155
  • ENST00000515765
  • ENSP00000426232

Symbol
  • KIAA1123
  • NBR13
  • SCA42
  • Cav3.1
  • SCA42ND
  • Ca(V)T.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
molecular function
0.86
transcription factor
0.83
PubMedID
0.76
protein domain
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.54   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.54   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 511
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8