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Tchem
CACNA1F
Voltage-dependent L-type calcium channel subunit alpha-1F

Protein Summary
Description
Isoform 1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization. Isoform 4: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations. Isoform 6: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323022
  • ENSP00000321618
  • ENSG00000102001
  • ENST00000376251
  • ENSP00000365427
  • ENST00000376265
  • ENSP00000365441

Symbol
  • CACNAF1
  • JM8
  • OA2
  • AIED
  • COD3
  • COD4
  • JMC8
  • CORDX
  • CSNB2
  • CORDX3
  • CSNB2A
  • CSNBX2
  • Cav1.4
  • Cav1.4alpha1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
cellular component
0.79
biological process
0.71
cell type or tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.63   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.63   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (166)
CACNB1
Tbio
Family:  IC
Novelty:  0.06568749
Score:  0.986
Data Source:  Reactome,STRINGDB
CACNB2
Tbio
Family:  IC
Novelty:  0.01745218
Score:  0.986
Data Source:  Reactome,STRINGDB
CACNA2D4
Tbio
Family:  IC
Novelty:  0.02238343
Score:  0.977
Data Source:  Reactome,STRINGDB
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
Score:  0.974
Data Source:  Reactome,STRINGDB
CACNB4
Tbio
Family:  IC
Novelty:  0.01564026
Score:  0.965
Data Source:  Reactome,STRINGDB
CACNG1
Tbio
Family:  IC
Novelty:  0.11899252
Score:  0.964
Data Source:  STRINGDB
CACNA2D2
Tclin
Family:  IC
Novelty:  0.02041017
Score:  0.963
Data Source:  Reactome,STRINGDB
CACNB3
Tbio
Family:  IC
Novelty:  0.04007679
Score:  0.955
Data Source:  Reactome,STRINGDB
CACNA2D3
Tbio
Family:  IC
Novelty:  0.05267262
Score:  0.949
Data Source:  Reactome,STRINGDB
CACNG8
Tdark
Family:  IC
Novelty:  0.26770379
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 5
HTR2B
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
HTR2C
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
HTR2A
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
Pathways (35)
Cardiac conduction (R-HSA-5576891)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Reactome
Phase 2 - plateau phase
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
46.1
childhood onset asthma
1
1
0
1
38.2
mean platelet volume
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
46.1
childhood onset asthma
0
1
38.2
mean platelet volume
1
13.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1859639
54652
Rat
RGD:621535
114493
Dog
calcium voltage-gated channel subunit alpha1 F
VGNC:38636
480915
Horse
calcium voltage-gated channel subunit alpha1 F
VGNC:15985
100062861
Cow
calcium voltage-gated channel subunit alpha1 F
VGNC:26676
509779
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
calcium voltage-gated channel subunit alpha1 F
Horse
calcium voltage-gated channel subunit alpha1 F
Cow
calcium voltage-gated channel subunit alpha1 F
Publication Statistics
PubMed Score 239.63
PubMed score by year
PubTator Score 123.97
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title