Tchem CACNA1F Voltage-dependent L-type calcium channel subunit alpha-1F

Protein Summary

Description

Isoform 1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization. Isoform 4: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations. Isoform 6: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations. This gene encodes a multipass transmembrane protein that functions as an alpha-1 subunit of the voltage-dependent calcium channel, which mediates the influx of calcium ions into the cell. The encoded protein forms a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Mutations in this gene can cause X-linked eye disorders, including congenital stationary night blindness type 2A, cone-rod dystropy, and Aland Island eye disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• O60840
• A6NI29
• F5CIQ9
• O43901
• O95226
• Q9UHB1

Gene Name

• CACNA1F

Ensembl ID

• ENST00000323022
• ENSP00000321618
• ENSG00000102001
• ENST00000376251
• ENSP00000365427
• ENST00000376265
• ENSP00000365441

Symbol

• CACNAF1
• JM8
• OA2
• AIED
• COD3
• COD4
• JMC8
• CORDX
• CSNB2
• CORDX3
• CSNB2A
• CSNBX2
• Cav1.4
• Cav1.4alpha1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
protein domain	0.85
cellular component	0.79
biological process	0.71
cell type or tissue	0.69

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Alpha-1 Subunit Family / Cacna1f Subfamily / Voltage-dependent L-type Calcium Channel Subunit Alpha-1f

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.7   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.7   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5