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Tchem
CACNA1F
Voltage-dependent L-type calcium channel subunit alpha-1F

Protein Summary
Description
Isoform 1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization. Isoform 4: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations. Isoform 6: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323022
  • ENSP00000321618
  • ENSG00000102001
  • ENST00000376251
  • ENSP00000365427
  • ENST00000376265
  • ENSP00000365441

Symbol
  • CACNAF1
  • JM8
  • OA2
  • AIED
  • COD3
  • COD4
  • JMC8
  • CORDX
  • CSNB2
  • CORDX3
  • CSNB2A
  • CSNBX2
  • Cav1.4
  • Cav1.4alpha1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
cellular component
0.79
biological process
0.71
cell type or tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.7   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.7   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5