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Tclin
CACNA1D
Voltage-dependent L-type calcium channel subunit alpha-1D

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288139
  • ENSP00000288139
  • ENSG00000157388
  • ENST00000350061
  • ENSP00000288133
  • ENST00000422281
  • ENSP00000409174
  • ENST00000645528
  • ENSP00000494413

Symbol
  • CACH3
  • CACN4
  • CACNL1A2
  • CCHL1A2
  • CACH3
  • CACN4
  • PASNA
  • SANDD
  • Cav1.3
  • CCHL1A2
  • CACNL1A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
trait
0.93
protein domain
0.85
transcription factor
0.83
drug
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.42   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.42   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 24