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Tclin
CACNA1B
Voltage-dependent N-type calcium channel subunit alpha-1B

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277551
  • ENSP00000277551
  • ENSG00000148408
  • ENST00000371372
  • ENSP00000360423

Symbol
  • CACH5
  • CACNL1A5
  • BIII
  • CACNN
  • DYT23
  • Cav2.2
  • CACNL1A5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.85
disease perturbation
0.79
virus perturbation
0.79
cellular component
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.94   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.94   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 336
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (203)
CACNB3
Tbio
Family:  IC
Novelty:  0.04007679
Score:  0.988
Data Source:  Reactome,STRINGDB
CACNA2D2
Tclin
Family:  IC
Novelty:  0.02041017
Score:  0.953
Data Source:  STRINGDB
CACNA2D3
Tbio
Family:  IC
Novelty:  0.05267262
Score:  0.945
Data Source:  STRINGDB
CACNG2
Tbio
Family:  IC
Novelty:  0.00808502
Score:  0.938
Data Source:  Reactome,STRINGDB
CACNB4
Tbio
Family:  IC
Novelty:  0.01564026
Score:  0.911
Data Source:  STRINGDB
CACNB2
Tbio
Family:  IC
Novelty:  0.01745218
Score:  0.908
Data Source:  STRINGDB
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
Score:  0.9
Data Source:  STRINGDB
CACNB1
Tbio
Family:  IC
Novelty:  0.06568749
Score:  0.868
Data Source:  STRINGDB
CACNA2D4
Tbio
Family:  IC
Novelty:  0.02238343
Score:  0.865
Data Source:  STRINGDB
CACNG3
Tbio
Family:  IC
Novelty:  0.32654561
Score:  0.854
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Presynaptic depolarization and calcium channel opening
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Presynaptic depolarization and calcium channel opening
Transmission across Chemical Synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 B
464893
Mouse
MGI:88296
12287
Rat
RGD:628852
257648
Dog
calcium voltage-gated channel subunit alpha1 B
VGNC:38632
480660
Horse
calcium voltage-gated channel subunit alpha1 B
VGNC:15981
100058760
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 B
Mouse
Rat
Dog
calcium voltage-gated channel subunit alpha1 B
Horse
calcium voltage-gated channel subunit alpha1 B
Publication Statistics
PubMed Score 331.94
PubMed score by year
PubTator Score 281.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title