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Tchem
CACNA1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360228
  • ENSP00000353362
  • ENSG00000141837
  • ENST00000637276
  • ENSP00000489777
  • ENST00000637432
  • ENSP00000490617
  • ENST00000638009
  • ENSP00000489913

Symbol
  • CACH4
  • CACN3
  • CACNL1A4
  • BI
  • EA2
  • FHM
  • MHP
  • APCA
  • HPCA
  • MHP1
  • SCA6
  • CAV2.1
  • EIEE42
  • CACNL1A4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.93
molecular function
0.93
cellular component
0.84
phenotype
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1835.2   (req: < 5)
Gene RIFs: 171   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1835.2   (req: >= 5)
Gene RIFs: 171   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1