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Tbio
CABYR
Calcium-binding tyrosine phosphorylation-regulated protein

Protein Summary
Description
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium. To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327201
  • ENSP00000317095
  • ENSG00000154040
  • ENST00000399481
  • ENSP00000382404
  • ENST00000399496
  • ENSP00000382419
  • ENST00000399499
  • ENSP00000382421
  • ENST00000415309
  • ENSP00000399973
  • ENST00000463087
  • ENSP00000432870
  • ENST00000486759
  • ENSP00000431142
  • ENST00000621648
  • ENSP00000483621

Symbol
  • CBP86
  • FSP2
  • CT88
  • FSP2
  • CBP86
  • FSP-2
  • CABYRa
  • CABYRc
  • CABYRe
  • CABYRc/d
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
cell type or tissue
0.71
tissue sample
0.66
transcription factor
0.66
cellular component
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.21   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.21   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
FSCB
Tdark
Novelty:  0.19001656
Score:  0.928
Data Source:  STRINGDB
ROPN1
Tbio
Novelty:  0.05375245
Score:  0.907
Data Source:  STRINGDB
ROPN1L
Tbio
Novelty:  0.18077695
Score:  0.903
Data Source:  STRINGDB
AKAP3
Tbio
Family:  Enzyme
Novelty:  0.030936
Score:  0.894
Data Source:  STRINGDB
SPA17
Tbio
Novelty:  0.02632554
Score:  0.813
Data Source:  STRINGDB
AKAP4
Tbio
Family:  Enzyme
Novelty:  0.00760557
Score:  0.736
Data Source:  STRINGDB
RHPN1
Tbio
Novelty:  0.05722992
Score:  0.727
Data Source:  STRINGDB
PRKAR2A
Tchem
Family:  Enzyme
Novelty:  0.06183318
Score:  0.717
Data Source:  STRINGDB
CCDC63
Tbio
Novelty:  0.11520913
Score:  0.663
Data Source:  STRINGDB
TCP11L2
Tdark
Novelty:  1.78903335
Score:  0.625
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
2
2
82
monocyte percentage of leukocytes
1
1
1
61
leukocyte count
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
82
monocyte percentage of leukocytes
1
61
leukocyte count
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium binding tyrosine phosphorylation regulated
VGNC:8869
455342
Macaque
calcium binding tyrosine phosphorylation regulated
701670
Mouse
MGI:1918382
71132
Rat
RGD:1585413
686189
Dog
calcium binding tyrosine phosphorylation regulated
VGNC:38629
100270706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium binding tyrosine phosphorylation regulated
Macaque
calcium binding tyrosine phosphorylation regulated
Mouse
Rat
Dog
calcium binding tyrosine phosphorylation regulated
Publication Statistics
PubMed Score 26.21
PubMed score by year
PubTator Score 16.82
PubTator score by year
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Related Publications
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PMID
Year
Title