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Tclin
CA6
Carbonic anhydrase 6

Protein Summary
Description
Reversible hydration of carbon dioxide. Its role in saliva is unknown. The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377436
  • ENSP00000366654
  • ENSG00000131686
  • ENST00000377442
  • ENSP00000366661
  • ENST00000377443
  • ENSP00000366662

Symbol
  • CA-VI
  • GUSTIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
protein domain
0.58
hub protein
0.53
cell line
0.5
cellular component
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.77   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.77   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 221
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 15
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (15)
imatinib
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topiramate
Rendered image for topiramate
nilotinib
Rendered image for nilotinib
celecoxib
Rendered image for celecoxib
acetazolamide
Rendered image for acetazolamide
indapamide
Rendered image for indapamide
ethoxzolamide
Rendered image for ethoxzolamide
furosemide
Rendered image for furosemide
lacosamide
Rendered image for lacosamide
brinzolamide
Rendered image for brinzolamide
Active Ligands (221)
Protein-Protein Interactions (62)
IMMP1L
Tbio
Family:  Enzyme
Novelty:  0.16680031
p_int:  0.999818441
p_ni:  0.000006875
p_wrong:  0.000174684
Data Source:  BioPlex
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.996660743
p_ni:  1.47e-7
p_wrong:  0.00333911
Score:  0.214
Data Source:  BioPlex,STRINGDB
DCAF6
Tbio
Novelty:  0.01269552
p_int:  0.99624259
p_ni:  0.00375741
Data Source:  BioPlex
RHOBTB3
Tbio
Novelty:  0.09149494
p_int:  0.995268753
p_ni:  0.004730619
p_wrong:  6.28e-7
Data Source:  BioPlex
PLXNA2
Tbio
Novelty:  0.01765957
p_int:  0.968383279
p_ni:  0.03161651
p_wrong:  2.11e-7
Data Source:  BioPlex
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.947034772
p_ni:  0.052965228
Score:  0.206
Data Source:  BioPlex,STRINGDB
PTCD2
Tdark
Novelty:  0.23529342
p_int:  0.897044179
p_ni:  0.102953534
p_wrong:  0.000002286
Data Source:  BioPlex
NPC2
Tbio
Novelty:  0.00342898
p_int:  0.884832802
p_ni:  0.115167017
p_wrong:  1.81e-7
Data Source:  BioPlex
LAMB2
Tbio
Novelty:  0.07966931
p_int:  0.834284754
p_ni:  0.165715246
Data Source:  BioPlex
PLXNA3
Tbio
Novelty:  0.02016528
p_int:  0.831823608
p_ni:  0.168176392
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Metabolism
Reversible hydration of carbon dioxide
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
91.8
platelet crit
2
2
2
86.4
myeloid white cell count
2
2
2
82.2
lymphocyte percentage of leukocytes
1
1
1
49.5
basophil count
2
2
2
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
91.8
platelet crit
2
86.4
myeloid white cell count
2
82.2
lymphocyte percentage of leukocytes
1
49.5
basophil count
2
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 6
VGNC:9850
457915
Macaque
carbonic anhydrase 6
709540
Mouse
MGI:1333786
12353
Rat
RGD:70516
298657
Dog
carbonic anhydrase 6
VGNC:38614
403503
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 6
Macaque
carbonic anhydrase 6
Mouse
Rat
Dog
carbonic anhydrase 6
Publication Statistics
PubMed Score 355.77
PubMed score by year
PubTator Score 138.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title