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Tclin
CA2
Carbonic anhydrase 2

Protein Summary
Description
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285379
  • ENSP00000285379
  • ENSG00000104267

Symbol
  • CAC
  • CAII
  • Car2
  • CA-II
  • HEL-76
  • HEL-S-282
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
gene perturbation
1
disease perturbation
0.98
transcription factor perturbation
0.97
biological term
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2344.5   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 579   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2344.5   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 579   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5733
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 24
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (24)
imatinib
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topiramate
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nilotinib
Rendered image for nilotinib
celecoxib
Rendered image for celecoxib
acetazolamide
Rendered image for acetazolamide
indapamide
Rendered image for indapamide
ethoxzolamide
Rendered image for ethoxzolamide
furosemide
Rendered image for furosemide
lacosamide
Rendered image for lacosamide
brinzolamide
Rendered image for brinzolamide
Active Ligands (5733)
Protein-Protein Interactions (118)
CDH1
Tbio
Novelty:  0.00010629
Score:  0.925
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.916
Data Source:  STRINGDB
CTNND1
Tbio
Novelty:  0.00335459
Score:  0.905
Data Source:  STRINGDB
AFDN
Tbio
Novelty:  0.00372947
Score:  0.9
Data Source:  STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.9
Data Source:  STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.9
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.9
Data Source:  STRINGDB
SLC9A1
Tchem
Family:  Transporter
Novelty:  0.00096678
Score:  0.878
Data Source:  STRINGDB
TDG
Tbio
Family:  Enzyme
Novelty:  0.00283178
Score:  0.874
Data Source:  STRINGDB
SLC4A4
Tbio
Family:  Transporter
Novelty:  0.00352439
Score:  0.8
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Reactome
Erythrocytes take up oxygen and release carbon dioxide
Reactome
Metabolism
Reactome
O2/CO2 exchange in erythrocytes
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Metabolism
O2/CO2 exchange in erythrocytes
Reversible hydration of carbon dioxide
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
91.1
glomerular filtration rate
1
1
1
50.6
mean corpuscular hemoglobin concentration
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
91.1
glomerular filtration rate
1
50.6
mean corpuscular hemoglobin concentration
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 2
VGNC:10214
450162
Macaque
carbonic anhydrase 2
574263
Mouse
MGI:88269
12349
Rat
RGD:2240
54231
Dog
carbonic anhydrase 2
VGNC:38610
477928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 2
Macaque
carbonic anhydrase 2
Mouse
Rat
Dog
carbonic anhydrase 2
Publication Statistics
PubMed Score 2344.50
PubMed score by year
PubTator Score 4135.00
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title