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Tbio
CA10
Carbonic anhydrase-related protein 10

Protein Summary
Description
Does not have a catalytic activity. This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the central nervous system, especially in brain development. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285273
  • ENSP00000285273
  • ENSG00000154975
  • ENST00000442502
  • ENSP00000390666
  • ENST00000451037
  • ENSP00000405388
  • ENST00000570565
  • ENSP00000459619

Symbol
  • CARPX
  • CA-RPX
  • HUCEP-15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
gene perturbation
0.76
phenotype
0.71
disease
0.65
cell type or tissue
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1293.6   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1293.6   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (152)
MTERF4
Tbio
Novelty:  0.17764705
p_int:  0.999999594
p_ni:  3.87e-7
p_wrong:  1.9e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.999999223
p_ni:  2.1e-8
p_wrong:  7.56e-7
Score:  0.309
Data Source:  BioPlex,STRINGDB
WDHD1
Tbio
Novelty:  0.01511313
p_int:  0.999998758
p_ni:  0.00000122
p_wrong:  2.2e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
PPRC1
Tbio
Novelty:  0.00182088
p_int:  0.999998575
p_ni:  4.16e-7
p_wrong:  0.000001009
Score:  0.228
Data Source:  BioPlex,STRINGDB
CALCOCO1
Tbio
Novelty:  0.17497928
p_int:  0.999993418
p_ni:  0.000006582
Data Source:  BioPlex
IMPACT
Tbio
Novelty:  0.05823777
p_int:  0.999981766
p_ni:  0.000018206
p_wrong:  2.7e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
NSUN4
Tbio
Family:  Enzyme
Novelty:  0.15593771
p_int:  0.99979879
p_ni:  0.000201193
p_wrong:  1.7e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
PHYHIP
Tdark
Family:  Enzyme
Novelty:  0.25773185
p_int:  0.99958049
p_ni:  0.000171509
p_wrong:  0.000248
Score:  0.536
Data Source:  BioPlex,STRINGDB
TSC22D1
Tbio
Family:  TF
Novelty:  0.01934962
p_int:  0.999193439
p_ni:  0.000806561
p_wrong:  1e-9
Score:  0.217
Data Source:  BioPlex,STRINGDB
ASS1
Tbio
Family:  Enzyme
Novelty:  0.00358761
p_int:  0.998622124
p_ni:  0.001377876
Score:  0.207
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
5
5
83.5
smoking status measurement
2
3
4
79.6
blood protein measurement
1
2
2
77.3
antisocial behaviour measurement
1
1
1
69.1
1
1
1
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
5
83.5
smoking status measurement
4
79.6
blood protein measurement
2
77.3
antisocial behaviour measurement
1
69.1
1
69.1
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
carbonic anhydrase 10
704971
Mouse
MGI:1919855
72605
Dog
carbonic anhydrase 10
VGNC:38605
609477
Horse
carbonic anhydrase 10
VGNC:15959
100056500
Cow
carbonic anhydrase 10
VGNC:26648
535917
Species
Name
OMA
EggNOG
Inparanoid
Macaque
carbonic anhydrase 10
Mouse
Dog
carbonic anhydrase 10
Horse
carbonic anhydrase 10
Cow
carbonic anhydrase 10
Publication Statistics
PubMed Score 1293.60
PubMed score by year
PubTator Score 52.36
PubTator score by year
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Related Publications
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PMID
Year
Title