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Tclin
CA1
Carbonic anhydrase 1

Protein Summary
Description
Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431316
  • ENSP00000392338
  • ENSG00000133742
  • ENST00000523022
  • ENSP00000429798
  • ENST00000523953
  • ENSP00000430656
  • ENST00000542576
  • ENSP00000443517

Symbol
  • CAB
  • CA-I
  • Car1
  • HEL-S-11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.89
cell type or tissue
0.76
chemical
0.69
molecular function
0.6
gene perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1776.15   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 583   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1776.15   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 583   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3736
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (20)
imatinib
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topiramate
Rendered image for topiramate
nilotinib
Rendered image for nilotinib
acetazolamide
Rendered image for acetazolamide
indapamide
Rendered image for indapamide
ethoxzolamide
Rendered image for ethoxzolamide
furosemide
Rendered image for furosemide
lacosamide
Rendered image for lacosamide
brinzolamide
Rendered image for brinzolamide
dichlorphenamide
Rendered image for dichlorphenamide
Active Ligands (3736)
Protein-Protein Interactions (45)
UPF3A
Tbio
Novelty:  0.01431609
p_int:  0.999999852
p_ni:  1.46e-7
p_wrong:  2e-9
Score:  0.379
Data Source:  BioPlex,STRINGDB
STAT4
Tchem
Family:  TF
Novelty:  0.00251747
Score:  0.9
Data Source:  STRINGDB
CYP24A1
Tchem
Family:  Enzyme
Novelty:  0.00107155
Score:  0.836
Data Source:  STRINGDB
SLC4A1
Tbio
Family:  Transporter
Novelty:  0.00290106
Score:  0.805
Data Source:  STRINGDB
AHSP
Tbio
Novelty:  0.00996928
Score:  0.789
Data Source:  STRINGDB
EPB42
Tbio
Family:  Enzyme
Novelty:  0.06393286
Score:  0.775
Data Source:  STRINGDB
ALAS2
Tbio
Family:  Enzyme
Novelty:  0.00491418
Score:  0.753
Data Source:  STRINGDB
GYPB
Tbio
Novelty:  0.00442195
Score:  0.747
Data Source:  STRINGDB
HAS1
Tbio
Family:  Enzyme
Novelty:  0.02014779
Score:  0.741
Data Source:  STRINGDB
HBD
Tbio
Novelty:  0.00203187
Score:  0.689
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Reactome
Erythrocytes take up oxygen and release carbon dioxide
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
3
6
94.1
reticulocyte measurement
3
3
3
93.6
mean reticulocyte volume
1
1
1
79.9
mean corpuscular volume
1
1
1
72.6
glomerular filtration rate
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
94.1
reticulocyte measurement
3
93.6
mean reticulocyte volume
1
79.9
mean corpuscular volume
1
72.6
glomerular filtration rate
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 1
VGNC:10213
464264
Macaque
carbonic anhydrase 1
703701
Mouse
MGI:88268
12346
Rat
RGD:1309780
310218
Dog
carbonic anhydrase 1
VGNC:38604
487031
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 1
Macaque
carbonic anhydrase 1
Mouse
Rat
Dog
carbonic anhydrase 1
Publication Statistics
PubMed Score 1776.15
PubMed score by year
PubTator Score 4756.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title