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Tbio
KBTBD13
Kelch repeat and BTB domain-containing protein 13

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The gene belongs to a family of genes encoding proteins containing a BTB domain and several kelch repeats. The BTB domain functions as a protein-protein interaction module, which includes an ability to self-associate or to interact with non-BTB domain-containing proteins. The kelch motif typically occurs in groups of five to seven repeats, and has been found in proteins with diverse functions. Known functions of these family members include transcription regulation, ion channel tetramerization and gating, protein ubiquitination or degradation, and cytoskeleton regulation. The exact function of this family member has yet to be determined. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432196
  • ENSP00000388723
  • ENSG00000234438

Symbol
  • NEM6
  • HCG1645727
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
microRNA
0.57
cell line
0.54
PubMedID
0.5
tissue
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (328)
1 – 10 of 328
CUL3
Tbio
Novelty:  0.0028737
Score:  0.98
Data Source:  STRINGDB
KLHL41
Tbio
Novelty:  0.03973182
Score:  0.942
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.942
Data Source:  STRINGDB
ASB10
Tbio
Novelty:  0.08667666
Score:  0.933
Data Source:  STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
Score:  0.928
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.927
Data Source:  STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.927
Data Source:  STRINGDB
UBE2O
Tbio
Novelty:  0.07084123
Score:  0.921
Data Source:  STRINGDB
UBE2Z
Tbio
Novelty:  0.11461616
Score:  0.921
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.92
Data Source:  STRINGDB
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
2
2
1
5.7
31.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
1
5.7
31.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch repeat and BTB domain containing 13
VGNC:11920
467706
Macaque
kelch repeat and BTB domain containing 13
708647
Mouse
MGI:1921742
74492
Cow
kelch repeat and BTB domain containing 13
VGNC:30414
527160
Opossum
kelch repeat and BTB domain containing 13
100024021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch repeat and BTB domain containing 13
Macaque
kelch repeat and BTB domain containing 13
Mouse
Cow
kelch repeat and BTB domain containing 13
Opossum
kelch repeat and BTB domain containing 13
Publication Statistics
PubMed Score 9.68
PubMed score by year
PubTator Score 3.79
PubTator score by year