C4BPA
C4b-binding protein alpha chain
Protein Summary
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also fou ...more
- ENST00000367070
- ENSP00000356037
- ENSG00000123838
- C4BP
- PRP
- C4BP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.65 | ||
biological term | 0.58 | ||
cell line | 0.52 | ||
small molecule perturbation | 0.51 | ||
virus perturbation | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 270.04 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 253 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 270.04 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 253 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (70)
Nearest Tclin Targets
Pathways (11)
Reactome (4)
KEGG (2)
PathwayCommons (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Regulation of Complement cascade | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Complement cascade | ||||
Immune System | ||||
Innate Immune System | ||||
Regulation of Complement cascade | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 3 | 3 | 91.7 | |||||
glomerular filtration rate | 2 | 2 | 2 | 75.4 | |||||
creatinine measurement | 1 | 1 | 1 | 62.6 | |||||
diastolic blood pressure | 1 | 1 | 1 | 49.5 | |||||
3 | 1 | 1 | 1.1 | 45.2 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 91.7 | |||||
glomerular filtration rate | 2 | 75.4 | |||||
creatinine measurement | 1 | 62.6 | |||||
diastolic blood pressure | 1 | 49.5 | |||||
1 | 1.1 | 45.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | complement component 4 binding protein alpha | VGNC:8241 | 457688 | |||||
Macaque | C4b-binding protein alpha chain | 693382 | ||||||
Mouse | MGI:104965 | 22789 | ||||||
Rat | RGD:2235 | 24235 | ||||||
Dog | complement component 4 binding protein alpha | VGNC:38593 | 100687316 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | complement component 4 binding protein alpha | |||||
Macaque | C4b-binding protein alpha chain | |||||
Mouse | ||||||
Rat | ||||||
Dog | complement component 4 binding protein alpha | |||||
Publication Statistics
PubMed Score 270.04
PubMed score by year
PubTator Score 551.14
PubTator score by year
Related Publications
Text Mined References (72)
GeneRif Annotations (40)
Items per page:
0 of 0
PMID | Year | Title |
|---|