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Tbio
C4B
Complement C4-B

Protein Summary
Description
Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375177
  • ENSP00000364321
  • ENSG00000228454
  • ENST00000411583
  • ENSP00000407942
  • ENSG00000228267
  • ENST00000435363
  • ENSP00000415941
  • ENSG00000224389
  • ENST00000435500
  • ENSP00000412786
  • ENSG00000233312
  • ENST00000449788
  • ENSP00000414200
  • ENSG00000236625

Symbol
  • CO4
  • CPAMD3
  • CH
  • C4F
  • CO4
  • C4B1
  • C4B2
  • C4B3
  • C4B5
  • C4BD
  • C4B12
  • C4B_2
  • CPAMD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
biological term
0.82
small molecule perturbation
0.81
cell line
0.68
disease
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1541.33   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1541.33   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (189)
C4A
Tbio
Novelty:  0.00062793
Score:  0.995
Data Source:  Reactome,STRINGDB
CD46
Tbio
Novelty:  0.00098341
Score:  0.992
Data Source:  Reactome,STRINGDB
CR1
Tbio
Novelty:  0.00157449
Score:  0.991
Data Source:  Reactome,STRINGDB
MASP2
Tchem
Family:  Enzyme
Novelty:  0.00466852
Score:  0.986
Data Source:  Reactome,STRINGDB
C1S
Tchem
Novelty:  0.00043003
Score:  0.983
Data Source:  Reactome,STRINGDB
CFB
Tchem
Novelty:  0.00102672
Score:  0.982
Data Source:  STRINGDB
C4BPA
Tbio
Novelty:  0.00319944
Score:  0.977
Data Source:  Reactome,STRINGDB
C1R
Tclin
Novelty:  0.00210654
Score:  0.977
Data Source:  Reactome,STRINGDB
C2
Tchem
Novelty:  0.00974862
Score:  0.976
Data Source:  Reactome,STRINGDB
MASP1
Tchem
Family:  Enzyme
Novelty:  0.0029019
Score:  0.975
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (148)
Activation of C3 and C5 (R-HSA-174577)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of C3 and C5
Reactome
Complement cascade
Reactome
Immune System
Reactome
Initial triggering of complement
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Activation of C3 and C5
Complement cascade
Immune System
Initial triggering of complement
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (284)
Items per page:
1 – 5 of 284
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
10
0
1.9
99.3
9
10
0
1.9
99.3
9
10
0
1.9
99.3
9
9
0
1.9
99.3
6
5
0
2.3
99
Items per page:
1 – 5 of 284
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
99.3
0
1.9
99.3
0
1.9
99.3
0
1.9
99.3
0
2.3
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88228
12268
Rat
RGD:9245878
103689965
Dog
complement C4-A
481722
Horse
complement C4-A
100059239
Cow
Bos taurus complement component 4A (C4A), mRNA. [Source:RefSeq mRNA;Acc:NM_001166485]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
complement C4-A
Horse
complement C4-A
Cow
Bos taurus complement component 4A (C4A), mRNA. [Source:RefSeq mRNA;Acc:NM_001166485]
Publication Statistics
PubMed Score 1541.33
PubMed score by year
PubTator Score 737.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title