Protein Summary
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of al ...more
- ENST00000383325
- ENSP00000372815
- ENSG00000206340
- ENST00000421274
- ENSP00000388662
- ENSG00000227746
- ENST00000428956
- ENSP00000396688
- ENSG00000244731
- ENST00000498271
- ENSP00000420212
- CO4
- CPAMD2
- C4
- RG
- C4S
- CO4
- C4A2
- C4A3
- C4A4
- C4A6
- C4AD
- CPAMD2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1687.23 (req: < 5)
Gene RIFs: 89 (req: <= 3)
Antibodies: 584 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1687.23 (req: >= 5)
Gene RIFs: 89 (req: > 3)
Antibodies: 584 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (311)
PVR
Novelty: 0.00215811
p_int: 0.999917355
p_ni: 0.000082645
p_wrong: 1e-9
Score: 0.199
Data Source: BioPlex,STRINGDB
GDPD1
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999543977
p_ni: 0.00039224
p_wrong: 0.000063782
Score: 0.153
Data Source: BioPlex,STRINGDB
SLC15A1
Family: Transporter
Novelty: 0.00149723
p_int: 0.999390947
p_ni: 0.000609053
Data Source: BioPlex
MSMB
Novelty: 0.00241546
p_int: 0.999372886
p_ni: 0.000382114
p_wrong: 0.000245
Data Source: BioPlex
FAM171B
Novelty: 0.38456365
p_int: 0.998677987
p_ni: 0.001322012
Score: 0.161
Data Source: BioPlex,STRINGDB
SCN2B
Family: IC
Novelty: 0.03773629
p_int: 0.998492802
p_ni: 0.001507148
p_wrong: 5e-8
Data Source: BioPlex
OCLN
Novelty: 0.00047671
p_int: 0.997900461
p_ni: 0.001475763
p_wrong: 0.000623776
Score: 0.155
Data Source: BioPlex,STRINGDB
CCL5
Novelty: 0.00032607
p_int: 0.996994267
p_ni: 0.002485949
p_wrong: 0.000519783
Score: 0.357
Data Source: BioPlex,STRINGDB
LGALS8
Novelty: 0.00623836
p_int: 0.996479377
p_ni: 0.003520384
p_wrong: 2.39e-7
Score: 0.168
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (40)
Reactome (10)
KEGG (4)
WikiPathways (26)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of C3 and C5 | ||||
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Initial triggering of complement | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of C3 and C5 | ||||
Complement cascade | ||||
Immune System | ||||
Initial triggering of complement | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (3)
Components (11)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (75)
Items per page:
1 – 5 of 75
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
9 | 10 | 0 | 1.9 | 99.3 | |||||
6 | 5 | 0 | 2.3 | 99 | |||||
2 | 4 | 0 | 1.9 | 98.3 | |||||
atrophic macular degeneration | 2 | 3 | 0 | 1.8 | 97.4 | ||||
leukocyte count | 3 | 3 | 4 | 97.3 | |||||
Items per page:
1 – 5 of 75
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.9 | 99.3 | |||||
0 | 2.3 | 99 | |||||
0 | 1.9 | 98.3 | |||||
atrophic macular degeneration | 0 | 1.8 | 97.4 | ||||
leukocyte count | 4 | 97.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Xenopus | complement component 4A (Rodgers blood group) | XB-GENE-478881 | 100135012 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Xenopus | complement component 4A (Rodgers blood group) | |||||
Publication Statistics
PubMed Score 1687.23
PubMed score by year
PubTator Score 2652.34
PubTator score by year
Related Publications
Text Mined References (157)
GeneRif Annotations (89)
Items per page:
0 of 0
PMID | Year | Title |
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