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Tbio
C2CD2L
Phospholipid transfer protein C2CD2L

Protein Summary
Description
Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336702
  • ENSP00000338885
  • ENSG00000172375
  • ENST00000648610
  • ENSP00000497391

Symbol
  • KIAA0285
  • TMEM24
  • DLNB23
  • TMEM24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
transcription factor binding site profile
0.71
virus perturbation
0.68
gene perturbation
0.62
tissue sample
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.91   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.91   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
p_int:  0.999696686
p_ni:  0.000303307
p_wrong:  7e-9
Data Source:  BioPlex
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
p_int:  0.999408644
p_ni:  0.000591328
p_wrong:  2.8e-8
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.998953968
p_ni:  0.001045624
p_wrong:  4.09e-7
Data Source:  BioPlex
PCDHA8
Tdark
Novelty:  0.57189179
p_int:  0.998452803
p_ni:  0.001546252
p_wrong:  9.45e-7
Data Source:  BioPlex
PRKCQ
Tchem
Family:  Kinase
Novelty:  0.00562719
p_int:  0.997651134
p_ni:  0.002328853
p_wrong:  0.000020012
Score:  0.235
Data Source:  BioPlex,STRINGDB
PCDHA12
Tdark
Novelty:  0.71618264
p_int:  0.996107584
p_ni:  0.003892218
p_wrong:  1.99e-7
Data Source:  BioPlex
PCDHB11
Tdark
Novelty:  0.80480462
p_int:  0.996101305
p_ni:  0.003898478
p_wrong:  2.16e-7
Data Source:  BioPlex
PCDHB16
Tdark
Novelty:  0.67206411
p_int:  0.991830584
p_ni:  0.008169413
p_wrong:  3e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.986714329
p_ni:  0.012925641
p_wrong:  0.00036003
Data Source:  BioPlex
PCDHAC2
Tdark
Novelty:  0.28397695
p_int:  0.978170792
p_ni:  0.021653808
p_wrong:  0.0001754
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
5
6.3
98.8
platelet crit
2
4
5
97.4
mean reticulocyte volume
1
2
2
94.6
lymphocyte count
3
3
3
88.2
body mass index
3
3
3
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
6.3
98.8
platelet crit
5
97.4
mean reticulocyte volume
2
94.6
lymphocyte count
3
88.2
body mass index
3
79.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C2CD2 like
VGNC:6760
451603
Macaque
C2CD2 like
703424
Mouse
MGI:1919014
71764
Rat
RGD:1310281
300666
Dog
C2CD2 like
VGNC:38589
610622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C2CD2 like
Macaque
C2CD2 like
Mouse
Rat
Dog
C2CD2 like
Publication Statistics
PubMed Score 5.91
PubMed score by year
PubTator Score 2.50
PubTator score by year
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Related Publications
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PMID
Year
Title