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Tdark
C2CD2
C2 domain-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329623
  • ENSP00000329302
  • ENSG00000157617
  • ENST00000380486
  • ENSP00000369853

Symbol
  • C21orf25
  • C21orf258
  • TMEM24L
  • TMEM24L
  • C21orf25
  • C21orf258
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor
0.71
microRNA
0.69
transcription factor binding site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
ARHGAP26
Tbio
Family:  Enzyme
Novelty:  0.02409941
p_int:  0.999999907
p_ni:  9.1e-8
p_wrong:  2e-9
Score:  0.826
Data Source:  BioPlex,STRINGDB
ARHGAP10
Tbio
Family:  Enzyme
Novelty:  0.22403346
p_int:  0.999999901
p_ni:  9.7e-8
p_wrong:  2e-9
Score:  0.912
Data Source:  BioPlex,STRINGDB
SEC14L1
Tbio
Novelty:  0.09562071
p_int:  0.999997213
p_ni:  0.000002787
Score:  0.538
Data Source:  BioPlex,STRINGDB
DYNC1LI2
Tbio
Novelty:  0.17381295
p_int:  0.893740887
p_ni:  0.106259113
Score:  0.323
Data Source:  BioPlex,STRINGDB
DYNC1LI1
Tbio
Novelty:  0.02164556
p_int:  0.882043633
p_ni:  0.117956367
Score:  0.345
Data Source:  BioPlex,STRINGDB
RBBP8NL
Tdark
Novelty:  3.33075673
Score:  0.753
Data Source:  STRINGDB
ADPRHL1
Tbio
Family:  Enzyme
Novelty:  0.3340174
Score:  0.718
Data Source:  STRINGDB
NOL9
Tdark
Family:  Enzyme
Novelty:  0.05830272
Score:  0.705
Data Source:  STRINGDB
ZNF805
Tdark
Family:  TF
Novelty:  2.14559387
Score:  0.702
Data Source:  STRINGDB
TRAPPC1
Tbio
Novelty:  0.09781468
Score:  0.679
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
48.6
a disintegrin and metalloproteinase with thrombospondin motifs 13
1
1
0
2.4
48.6
platelet crit
1
1
1
41.5
testosterone measurement
2
1
2
37.7
ceramide measurement
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
48.6
a disintegrin and metalloproteinase with thrombospondin motifs 13
0
2.4
48.6
platelet crit
1
41.5
testosterone measurement
2
37.7
ceramide measurement
1
15.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C2 calcium dependent domain containing 2
VGNC:14650
458574
Macaque
C2 calcium dependent domain containing 2
714860
Mouse
MGI:1891883
207781
Rat
RGD:735112
304055
Dog
C2 calcium dependent domain containing 2
VGNC:53020
487774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C2 calcium dependent domain containing 2
Macaque
C2 calcium dependent domain containing 2
Mouse
Rat
Dog
C2 calcium dependent domain containing 2
Publication Statistics
PubMed Score 2.02
PubMed score by year
PubTator Score 1.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title