Protein Summary
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provi ...more
- ENST00000299367
- ENSP00000299367
- ENSG00000166278
- ENST00000375510
- ENSP00000364660
- ENSG00000204364
- ENST00000383362
- ENSP00000372853
- ENSG00000206372
- ENST00000411803
- ENSP00000402278
- ENSG00000235696
- ENST00000413548
- ENSP00000407961
- ENSG00000231543
- ENST00000416252
- ENSP00000405800
- ENSG00000235017
- ENST00000442278
- ENSP00000395683
- ENST00000448206
- ENSP00000392835
- ENSG00000226560
- ENST00000452323
- ENSP00000392322
- ENST00000548973
- ENSP00000446728
- ENST00000548995
- ENSP00000449286
- ENST00000549972
- ENSP00000447632
- ENST00000550682
- ENSP00000446639
- ENST00000551081
- ENSP00000450387
- ENST00000551648
- ENSP00000449715
- ENST00000612228
- ENSP00000482616
- ENST00000615380
- ENSP00000481651
- ENST00000618254
- ENSP00000483231
- ENST00000621558
- ENSP00000480739
- CO2
- ARMD14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.97 | ||
protein domain | 0.92 | ||
virus perturbation | 0.9 | ||
disease | 0.79 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 80.32 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 448 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 80.32 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 448 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (77)
CD55
Novelty: 0.0005689
p_int: 0.999941524
p_ni: 0.000029745
p_wrong: 0.000028731
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (15)
Reactome (6)
KEGG (4)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of C3 and C5 | ||||
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Initial triggering of complement | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of C3 and C5 | ||||
Complement cascade | ||||
Immune System | ||||
Initial triggering of complement | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (158)
Items per page:
1 – 5 of 158
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
9 | 9 | 0 | 1.9 | 99.3 | ||||||
9 | 9 | 0 | 1.9 | 99.3 | ||||||
6 | 6 | 0 | 2.3 | 99.2 | ||||||
6 | 6 | 0 | 2.3 | 99.2 | ||||||
3 | 5 | 0 | 1.8 | 98.7 | ||||||
Items per page:
1 – 5 of 158
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.9 | 99.3 | |||||
0 | 1.9 | 99.3 | |||||
0 | 2.3 | 99.2 | |||||
0 | 2.3 | 99.2 | |||||
0 | 1.8 | 98.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | complement C2 | VGNC:11038 | 100608992 | |||||
Mouse | MGI:88226 | 12263 | ||||||
Horse | complement C2 | VGNC:15947 | 100059162 | |||||
Cow | complement C2 | VGNC:53959 | 515440 | |||||
Pig | complement C2 | 448981 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | complement C2 | |||||
Mouse | ||||||
Horse | complement C2 | |||||
Cow | complement C2 | |||||
Pig | complement C2 | |||||
Publication Statistics
PubMed Score 80.32
PubMed score by year
PubTator Score 41434.17
PubTator score by year
Related Publications
Text Mined References (114)
GeneRif Annotations (41)
Items per page:
0 of 0
PMID | Year | Title |
|---|