C2
Complement C2
Protein Summary
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provi ...more
- ENST00000299367
- ENSP00000299367
- ENSG00000166278
- ENST00000375510
- ENSP00000364660
- ENSG00000204364
- ENST00000383362
- ENSP00000372853
- ENSG00000206372
- ENST00000411803
- ENSP00000402278
- ENSG00000235696
- ENST00000413548
- ENSP00000407961
- ENSG00000231543
- ENST00000416252
- ENSP00000405800
- ENSG00000235017
- ENST00000442278
- ENSP00000395683
- ENST00000448206
- ENSP00000392835
- ENSG00000226560
- ENST00000452323
- ENSP00000392322
- ENST00000548973
- ENSP00000446728
- ENST00000548995
- ENSP00000449286
- ENST00000549972
- ENSP00000447632
- ENST00000550682
- ENSP00000446639
- ENST00000551081
- ENSP00000450387
- ENST00000551648
- ENSP00000449715
- ENST00000612228
- ENSP00000482616
- ENST00000615380
- ENSP00000481651
- ENST00000618254
- ENSP00000483231
- ENST00000621558
- ENSP00000480739
- CO2
- ARMD14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.97 | ||
protein domain | 0.92 | ||
virus perturbation | 0.9 | ||
disease | 0.79 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.15 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 448 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.15 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 448 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0