Tdark C1orf74 UPF0739 protein C1orf74

Protein Summary

Uniprot Accession IDs

• Q96LT6

Gene Name

• C1orf74

Ensembl ID

• ENST00000294811
• ENSP00000294811
• ENSG00000162757

Symbol

• URLC4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.16   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.16   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (13)

Explore Interacting Targets

1 – 10 of 13

• See Interactions on String-DB

BBOF1

Tdark

Novelty:  0.82370886

Score:  0.646

Data Source:  STRINGDB

RHEX

Tbio

Novelty:  0.20957256

Score:  0.632

Data Source:  STRINGDB

TRAF3IP3

Tbio

Novelty:  0.12180834

Score:  0.542

Data Source:  STRINGDB

EIF2D

Tbio

Novelty:  0.03765592

Score:  0.528

Data Source:  STRINGDB

SARG

Tbio

Novelty:  0.05063046

Score:  0.491

Data Source:  STRINGDB

FAM72A

Tbio

Novelty:  0.02842806

Score:  0.479

Data Source:  STRINGDB

DIEXF

Tbio

Novelty:  0.05892659

Score:  0.474

Data Source:  STRINGDB

YOD1

Tbio

Family:  Enzyme

Novelty:  0.05709057

Score:  0.44

Data Source:  STRINGDB

G0S2

Tbio

Novelty:  0.02273959

Score:  0.424

Data Source:  STRINGDB

AZIN1

Tbio

Family:  Enzyme

Novelty:  0.03017595

Score:  0.42

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations ()

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cleft lip	EFO_0003959	6	7	0	1.7	97.7
Cleft palate	HP_0000175	4	5	0	1.5	93.6
Oral cleft	HP_0000202	2	3	1	1.6	86.5
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		72.6
mean corpuscular volume	EFO_0004526	1	1	1		66.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cleft lip	EFO_0003959	0	1.7	97.7
Cleft palate	HP_0000175	0	1.5	93.6
Oral cleft	HP_0000202	1	1.6	86.5
mean corpuscular hemoglobin concentration	EFO_0004528	1		72.6
mean corpuscular volume	EFO_0004526	1		66.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

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Complete proteome
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
cleft lip
Cleft palate
erythrocyte count
inflammatory bowel disease
mean corpuscular hemoglobin concentration
mean corpuscular volume
Oral cleft
red blood cell density measurement
synophrys measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	chromosome 1 C1orf74 homolog	VGNC:4993	457700
Mouse	RIKEN cDNA A130010J15 gene	MGI:2441776	319266
Rat	hypothetical protein LOC100125367	RGD:1642423	100125367
Dog	chromosome 7 C1orf74 homolog	VGNC:52588	100687793
Horse	chromosome 5 C1orf74 homolog	VGNC:52337	100056345

Species	Name	OMA	EggNOG	Inparanoid
Chimp	chromosome 1 C1orf74 homolog
Mouse	RIKEN cDNA A130010J15 gene
Rat	hypothetical protein LOC100125367
Dog	chromosome 7 C1orf74 homolog
Horse	chromosome 5 C1orf74 homolog

Publication Statistics

PubMed Score 0.16

PubMed score by year

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Related Publications

Text Mined References (5)

Items per page:

10

0 of 0

PMID	Year	Title