Tdark C1orf159 Uncharacterized protein C1orf159

Protein Summary

Uniprot Accession IDs

• Q96HA4
• B3KQ46
• Q5T2W6
• Q6UX67
• Q6ZR77
• Q9NWV0

Gene Name

• C1orf159

Ensembl ID

• ENST00000379319
• ENSP00000368623
• ENSG00000131591
• ENST00000379325
• ENSP00000368629
• ENST00000379339
• ENSP00000368644
• ENST00000421241
• ENSP00000400736

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.3   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.3   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (3)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (12)

Explore Interacting Targets

1 – 10 of 12

• See Interactions on String-DB

LGALS8

Tchem

Novelty:  0.00623836

p_int:  0.999586253

p_ni:  0.000408952

p_wrong:  0.000004795

Data Source:  BioPlex

ARMC6

Tdark

Novelty:  0.58706267

p_int:  0.992639208

p_ni:  0.007355822

p_wrong:  0.00000497

Score:  0.235

Data Source:  BioPlex,STRINGDB

GBP5

Tbio

Novelty:  0.03705719

p_int:  0.963083589

p_ni:  0.010217201

p_wrong:  0.02669921

Score:  0.309

Data Source:  BioPlex,STRINGDB

LRRC55

Tbio

Family:  IC

Novelty:  0.25121277

p_int:  0.894153533

p_ni:  0.003784348

p_wrong:  0.102062119

Data Source:  BioPlex

OR10J3

Tdark

Family:  oGPCR

Novelty:  2.28918072

Score:  0.53

Data Source:  STRINGDB

COMMD4

Tbio

Novelty:  0.20453574

Score:  0.499

Data Source:  STRINGDB

PLEKHS1

Tbio

Novelty:  0.23671821

Score:  0.474

Data Source:  STRINGDB

UXS1

Tbio

Family:  Enzyme

Novelty:  0.04671281

Score:  0.446

Data Source:  STRINGDB

DENND4A

Tbio

Novelty:  0.22983311

Score:  0.445

Data Source:  STRINGDB

MACO1

Tbio

Novelty:  0.18252972

Score:  0.442

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein A 1 measurement	EFO_0004614	2	2	2		52
high density lipoprotein cholesterol measurement	EFO_0004612	2	2	2		47.4
hip bone size	EFO_0004844	1	1	1		31.4
calcium measurement	EFO_0004838	1	1	1		21.3
urate measurement	EFO_0004531	2	1	2		12.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein A 1 measurement	EFO_0004614	2		52
high density lipoprotein cholesterol measurement	EFO_0004612	2		47.4
hip bone size	EFO_0004844	1		31.4
calcium measurement	EFO_0004838	1		21.3
urate measurement	EFO_0004531	2		12.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Glycoprotein
Membrane
Reference proteome
Signal
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
calcium measurement
high density lipoprotein cholesterol measurement
hip bone size
urate measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	chromosome 1 open reading frame, human C1orf159		701238
Mouse	RIKEN cDNA 9430015G10 gene	MGI:2444364	230996
Rat	similar to RIKEN cDNA 9430015G10	RGD:1311517	313775
Dog	chromosome 5 C1orf159 homolog	VGNC:53311	606926

Species	Name	OMA	EggNOG	Inparanoid
Macaque	chromosome 1 open reading frame, human C1orf159
Mouse	RIKEN cDNA 9430015G10 gene
Rat	similar to RIKEN cDNA 9430015G10
Dog	chromosome 5 C1orf159 homolog

Publication Statistics

PubMed Score 0.30

PubMed score by year

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Related Publications

Text Mined References (7)

Items per page:

10

0 of 0

PMID	Year	Title