You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
C1QTNF4
Complement C1q tumor necrosis factor-related protein 4

Protein Summary
Description
May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302514
  • ENSP00000302274
  • ENSG00000172247
  • ENST00000642567
  • ENSP00000496508
  • ENSG00000284838

Symbol
  • CTRP4
  • CTRP4
  • ZACRP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
disease
0.58
histone modification site profile
0.52
PubMedID
0.47
tissue
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.43   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.43   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
ADIPOQ
Tbio
Novelty:  0.00011196
p_int:  0.999991484
p_wrong:  0.000008516
Data Source:  BioPlex
B4GALNT4
Tdark
Family:  Enzyme
Novelty:  0.19278471
Score:  0.756
Data Source:  STRINGDB
ILDR2
Tdark
Novelty:  0.2099634
Score:  0.739
Data Source:  STRINGDB
MXRA7
Tdark
Novelty:  0.20850504
Score:  0.573
Data Source:  STRINGDB
TMEM120A
Tdark
Novelty:  0.21664358
Score:  0.516
Data Source:  STRINGDB
CLASRP
Tbio
Novelty:  0.00582947
Score:  0.515
Data Source:  STRINGDB
HSF2BP
Tbio
Novelty:  0.18601995
Score:  0.508
Data Source:  STRINGDB
CCDC9
Tdark
Novelty:  0.73149492
Score:  0.5
Data Source:  STRINGDB
LRIG1
Tbio
Novelty:  0.01078663
Score:  0.492
Data Source:  STRINGDB
ITPRID1
Tdark
Novelty:  2.36881208
Score:  0.481
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
15
4
26
97.2
grip strength measurement
2
2
2
81.8
serum metabolite measurement
2
4
13
78.3
body height
1
1
1
78.1
comparative body size at age 10, self-reported
1
1
1
76.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
26
97.2
grip strength measurement
2
81.8
serum metabolite measurement
13
78.3
body height
1
78.1
comparative body size at age 10, self-reported
1
76.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C1q and TNF related 4
712839
Mouse
MGI:1914695
67445
Rat
RGD:1311006
311184
Dog
C1q and TNF related 4
VGNC:51856
483620
Pig
C1q and TNF related 4
100511621
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C1q and TNF related 4
Mouse
Rat
Dog
C1q and TNF related 4
Pig
C1q and TNF related 4
Publication Statistics
PubMed Score 14.43
PubMed score by year
PubTator Score 4.00
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title