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Tdark
C1QL4
Complement C1q-like protein 4

Protein Summary
Description
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334221
  • ENSP00000335285
  • ENSG00000186897

Symbol
  • CTRP11
  • CTRP11
  • C1QTNF11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.59
histone modification site profile
0.58
PubMedID
0.51
transcription factor
0.44
cell line
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.14   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.14   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
DUS3L
Tdark
Family:  Enzyme
Novelty:  0.24952542
p_int:  0.99999992
p_ni:  7.8e-8
p_wrong:  3e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.999783543
p_ni:  0.00021577
p_wrong:  6.87e-7
Score:  0.186
Data Source:  BioPlex,STRINGDB
COL10A1
Tbio
Novelty:  0.00521991
p_int:  0.999586311
p_ni:  0.000413689
Score:  0.202
Data Source:  BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int:  0.999522677
p_ni:  0.000477323
p_wrong:  1e-9
Data Source:  BioPlex
ADIPOQ
Tbio
Novelty:  0.00011196
p_int:  0.997084051
p_ni:  0.002824071
p_wrong:  0.000091878
Data Source:  BioPlex
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.996542344
p_ni:  0.003457652
p_wrong:  3e-9
Data Source:  BioPlex
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.995024629
p_ni:  0.003179166
p_wrong:  0.001796205
Data Source:  BioPlex
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.994489395
p_ni:  0.005510605
Score:  0.173
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.994355609
p_ni:  0.005643101
p_wrong:  0.000001289
Data Source:  BioPlex
COL14A1
Tbio
Novelty:  0.01760399
p_int:  0.987399425
p_ni:  0.012600575
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
90.2
platelet count
2
2
2
81.1
bone density
1
1
2
53.3
nerve conduction amplitude
1
1
1
50.6
self reported educational attainment
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
90.2
platelet count
2
81.1
bone density
2
53.3
nerve conduction amplitude
1
50.6
self reported educational attainment
1
35
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C1q like 4
VGNC:12851
466977
Macaque
complement C1q like 4
710018
Mouse
MGI:3579909
239659
Rat
RGD:1565968
300220
Dog
complement C1q like 4
VGNC:38581
608832
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C1q like 4
Macaque
complement C1q like 4
Mouse
Rat
Dog
complement C1q like 4
Publication Statistics
PubMed Score 3.14
PubMed score by year
PubTator Score 0.76
PubTator score by year
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Related Publications
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PMID
Year
Title