Tdark C1QL4 Complement C1q-like protein 4

Protein Summary

Description

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).

Uniprot Accession IDs

• Q86Z23

Gene Name

• C1QL4

Ensembl ID

• ENST00000334221
• ENSP00000335285
• ENSG00000186897

Symbol

• CTRP11
• CTRP11
• C1QTNF11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.59
histone modification site profile	0.58
PubMedID	0.51
transcription factor	0.44
cell line	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.14   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.14   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (51)

Explore Interacting Targets

1 – 10 of 51

• See Interactions on String-DB

DUS3L

Tdark

Family:  Enzyme

Novelty:  0.24952542

p_int:  0.99999992

p_ni:  7.8e-8

p_wrong:  3e-9

Score:  0.174

Data Source:  BioPlex,STRINGDB

KLHL11

Tbio

Novelty:  0.1537041

p_int:  0.999783543

p_ni:  0.00021577

p_wrong:  6.87e-7

Score:  0.186

Data Source:  BioPlex,STRINGDB

COL10A1

Tbio

Novelty:  0.00521991

p_int:  0.999586311

p_ni:  0.000413689

Score:  0.202

Data Source:  BioPlex,STRINGDB

HSP90AA5P

Tdark

p_int:  0.999522677

p_ni:  0.000477323

p_wrong:  1e-9

Data Source:  BioPlex

ADIPOQ

Tbio

Novelty:  0.00011196

p_int:  0.997084051

p_ni:  0.002824071

p_wrong:  0.000091878

Data Source:  BioPlex

SRC

Tclin

Family:  Kinase

Novelty:  0.00008479

p_int:  0.996542344

p_ni:  0.003457652

p_wrong:  3e-9

Data Source:  BioPlex

VHL

Tchem

Family:  Enzyme

Novelty:  0.00285782

p_int:  0.995024629

p_ni:  0.003179166

p_wrong:  0.001796205

Data Source:  BioPlex

PON2

Tbio

Family:  Enzyme

Novelty:  0.00414855

p_int:  0.994489395

p_ni:  0.005510605

Score:  0.173

Data Source:  BioPlex,STRINGDB

HTR3A

Tclin

Family:  IC

Novelty:  0.00217443

p_int:  0.994355609

p_ni:  0.005643101

p_wrong:  0.000001289

Data Source:  BioPlex

COL14A1

Tbio

Novelty:  0.01760399

p_int:  0.987399425

p_ni:  0.012600575

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (1)

Components (2)

Processes (3)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	2	3		90.2
platelet count	EFO_0004309	2	2	2		81.1
bone density	EFO_0003923	1	1	2		53.3
nerve conduction amplitude	EFO_0010070	1	1	1		50.6
self reported educational attainment	EFO_0004784	1	1	1		35

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3		90.2
platelet count	EFO_0004309	2		81.1
bone density	EFO_0003923	2		53.3
nerve conduction amplitude	EFO_0010070	1		50.6
self reported educational attainment	EFO_0004784	1		35

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Collagen
Complete proteome
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
bone density
cognitive function measurement
high density lipoprotein cholesterol measurement
intelligence
mean platelet volume
nerve conduction amplitude
platelet count
prostate carcinoma
self reported educational attainment

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	complement C1q like 4	VGNC:12851	466977
Macaque	complement C1q like 4		710018
Mouse	complement component 1, q subcomponent-like 4	MGI:3579909	239659
Rat	complement C1q like 4	RGD:1565968	300220
Dog	complement C1q like 4	VGNC:38581	608832

Species	Name	OMA	EggNOG	Inparanoid
Chimp	complement C1q like 4
Macaque	complement C1q like 4
Mouse	complement component 1, q subcomponent-like 4
Rat	complement C1q like 4
Dog	complement C1q like 4

Publication Statistics

PubMed Score 3.14

PubMed score by year

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PubTator Score 0.76

PubTator score by year

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Related Publications

Text Mined References (2)

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10

0 of 0

PMID	Year	Title