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Tbio
C1QA
Complement C1q subcomponent subunit A

Protein Summary
Description
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374642
  • ENSP00000363773
  • ENSG00000173372
  • ENST00000402322
  • ENSP00000385564
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.81
drug
0.79
biological term
0.73
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.42   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.42   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
C1QB
Tbio
Novelty:  0.01476497
Score:  0.999
Data Source:  Reactome,STRINGDB
C1QC
Tbio
Novelty:  0.0286777
Score:  0.997
Data Source:  Reactome,STRINGDB
C1R
Tclin
Novelty:  0.00210654
Score:  0.973
Data Source:  Reactome,STRINGDB
C1S
Tchem
Novelty:  0.00043003
Score:  0.971
Data Source:  Reactome,STRINGDB
VSIG4
Tbio
Novelty:  0.01671671
Score:  0.966
Data Source:  STRINGDB
SERPING1
Tbio
Family:  Enzyme
Novelty:  0.00068448
Score:  0.965
Data Source:  Reactome,STRINGDB
C4B
Tbio
Novelty:  0.00068357
Score:  0.957
Data Source:  Reactome,STRINGDB
C4A
Tbio
Novelty:  0.00062793
Score:  0.955
Data Source:  Reactome,STRINGDB
CRP
Tbio
Novelty:  0.00001517
Score:  0.95
Data Source:  Reactome,STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.932
Data Source:  STRINGDB
Pathways (18)
Classical antibody-mediated complement activation (R-HSA-173623)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Classical antibody-mediated complement activation
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Classical antibody-mediated complement activation
Complement cascade
Creation of C4 and C2 activators
Immune System
Initial triggering of complement
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
0
6.7
49.5
interferon gamma measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
0
6.7
49.5
interferon gamma measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C1q A chain
VGNC:12979
749231
Mouse
MGI:88223
12259
Rat
RGD:1306716
298566
Dog
complement C1q A chain
VGNC:38576
478194
Horse
complement C1q A chain
VGNC:15936
100058097
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C1q A chain
Mouse
Rat
Dog
complement C1q A chain
Horse
complement C1q A chain
Publication Statistics
PubMed Score 115.42
PubMed score by year
PubTator Score 2616.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title