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Tbio
C1GALT1
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Protein Summary
Description
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development. The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223122
  • ENSP00000223122
  • ENSG00000106392
  • ENST00000402468
  • ENSP00000384550
  • ENST00000436587
  • ENSP00000389176

Symbol
  • C1GALT
  • T-synthase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
transcription factor binding site profile
0.83
microRNA
0.77
phenotype
0.72
transcription factor
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.85   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.85   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
CD27
Tbio
Novelty:  0.00090508
p_int:  0.999988104
p_ni:  0.000011896
Score:  0.222
Data Source:  BioPlex,STRINGDB
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.999912938
p_ni:  0.000086828
p_wrong:  2.35e-7
Data Source:  BioPlex
NPPB
Tbio
Novelty:  0.00024947
p_int:  0.999792505
p_ni:  0.000204179
p_wrong:  0.000003316
Data Source:  BioPlex
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.999766073
p_ni:  0.00023366
p_wrong:  2.67e-7
Data Source:  BioPlex
CRP
Tbio
Novelty:  0.00001517
p_int:  0.999267601
p_ni:  0.00024213
p_wrong:  0.000490269
Score:  0.179
Data Source:  BioPlex,STRINGDB
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
p_int:  0.996606785
p_ni:  0.002553248
p_wrong:  0.000839967
Score:  0.191
Data Source:  BioPlex,STRINGDB
GALNT4
Tbio
Family:  Enzyme
Novelty:  0.05200323
Score:  0.973
Data Source:  STRINGDB
GALNT11
Tbio
Family:  Enzyme
Novelty:  0.09714947
Score:  0.972
Data Source:  STRINGDB
ST6GALNAC1
Tbio
Family:  Enzyme
Novelty:  0.00453853
Score:  0.97
Data Source:  STRINGDB
ST3GAL1
Tchem
Family:  Enzyme
Novelty:  0.01236776
Score:  0.969
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) (R-HSA-5083632)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
56
myeloid white cell count
1
1
1
54.4
monocyte count
1
1
1
50.6
aspartate aminotransferase measurement
1
1
0
6.7
49.5
serum galactose-deficient IgA1 measurement
2
2
2
49.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
56
myeloid white cell count
1
54.4
monocyte count
1
50.6
aspartate aminotransferase measurement
0
6.7
49.5
serum galactose-deficient IgA1 measurement
2
49.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2151071
94192
Rat
RGD:621105
65044
Dog
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
VGNC:38574
482314
Horse
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
VGNC:15934
100063865
Cow
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
VGNC:26615
539417
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Horse
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Cow
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Publication Statistics
PubMed Score 101.85
PubMed score by year
PubTator Score 44.45
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title