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Tbio
C1D
Nuclear nucleic acid-binding protein C1D

Protein Summary
Description
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355848
  • ENSP00000348107
  • ENSG00000197223
  • ENST00000409302
  • ENSP00000386779
  • ENST00000410067
  • ENSP00000386468

Symbol
  • LRP1
  • hC1D
  • Rrp47
  • SUNCOR
  • SUN-CoR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
histone modification site profile
0.81
transcription factor binding site profile
0.8
cell type or tissue
0.64
cellular component
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.67   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.67   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (198)
EXOSC8
Tbio
Family:  Enzyme
Novelty:  0.02013403
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC3
Tbio
Novelty:  0.03072164
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC1
Tbio
Novelty:  0.01386842
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC7
Tbio
Family:  Enzyme
Novelty:  0.07422851
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC10
Tbio
Novelty:  0.00335571
p_int:  0.999997815
p_ni:  0.000002185
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.999995418
p_ni:  0.000004583
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
EXOSC4
Tbio
Family:  Enzyme
Novelty:  0.00798796
p_int:  0.999952114
p_ni:  0.000047886
Score:  0.998
Data Source:  BioPlex,STRINGDB
RBM7
Tbio
Novelty:  0.07482689
p_int:  0.999862411
p_ni:  0.000137589
Score:  0.845
Data Source:  BioPlex,STRINGDB
EXOSC5
Tbio
Family:  Enzyme
Novelty:  0.03352493
p_int:  0.99975887
p_ni:  0.00024113
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC2
Tbio
Novelty:  0.08163283
p_int:  0.999662602
p_ni:  0.000337398
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
1
1
37.6
diastolic blood pressure change measurement
1
1
0
12
26.6
response to diuretic
1
1
0
12
26.6
hip circumference
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
37.6
diastolic blood pressure change measurement
0
12
26.6
response to diuretic
0
12
26.6
hip circumference
1
14.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C1D nuclear receptor corepressor
VGNC:178
745296
Mouse
MGI:1927354
57316
Rat
RGD:1560600
289810
Dog
C1D nuclear receptor corepressor
VGNC:38573
612549
Horse
C1D nuclear receptor corepressor
VGNC:15933
100061974
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C1D nuclear receptor corepressor
Mouse
Rat
Dog
C1D nuclear receptor corepressor
Horse
C1D nuclear receptor corepressor
Publication Statistics
PubMed Score 103.67
PubMed score by year
PubTator Score 33.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title