Tdark C18orf21 UPF0711 protein C18orf21

Protein Summary

Uniprot Accession IDs

• Q32NC0
• Q6GW03
• Q9BXV6
• Q9BXW2

Gene Name

• C18orf21

Ensembl ID

• ENST00000333234
• ENSP00000329492
• ENSG00000141428
• ENST00000592875
• ENSP00000465517
• ENST00000610527
• ENSP00000480486

Symbol

• XTP13
• XTP13
• HsT3108
• PNAS-124
• PNAS-131

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.81   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.81   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (37)

Explore Interacting Targets

1 – 10 of 37

• See Interactions on String-DB

RPP25

Tbio

Family:  Enzyme

Novelty:  0.07178063

p_int:  0.999999999

p_ni:  1e-9

Score:  0.873

Data Source:  BioPlex,STRINGDB

POP4

Tbio

Family:  Enzyme

Novelty:  0.01072287

p_int:  0.999999999

p_ni:  1e-9

Score:  0.827

Data Source:  BioPlex,STRINGDB

RPP30

Tbio

Family:  Enzyme

Novelty:  0.01375777

p_int:  0.999999422

p_ni:  5.78e-7

Score:  0.836

Data Source:  BioPlex,STRINGDB

RPP40

Tbio

Family:  Enzyme

Novelty:  0.05981624

p_int:  0.999995063

p_ni:  0.000004937

Score:  0.826

Data Source:  BioPlex,STRINGDB

RPP14

Tbio

Family:  Enzyme

Novelty:  0.10813341

p_int:  0.999986681

p_ni:  0.000009127

p_wrong:  0.000004192

Score:  0.855

Data Source:  BioPlex,STRINGDB

NEPRO

Tbio

Novelty:  0.12980261

p_int:  0.999937888

p_ni:  0.000062112

p_wrong:  1e-9

Score:  0.828

Data Source:  BioPlex,STRINGDB

RPP25L

Tdark

Family:  Enzyme

Novelty:  1.39761189

p_int:  0.999929139

p_ni:  0.000070861

Score:  0.816

Data Source:  BioPlex,STRINGDB

POP5

Tbio

Family:  Enzyme

Novelty:  0.02459167

p_int:  0.9998132

p_ni:  0.000071405

p_wrong:  0.000115395

Score:  0.869

Data Source:  BioPlex,STRINGDB

RPP38

Tbio

Family:  Enzyme

Novelty:  0.06387902

p_int:  0.998927545

p_ni:  0.001072454

p_wrong:  1e-9

Score:  0.806

Data Source:  BioPlex,STRINGDB

MECP2

Tchem

Family:  TF

Novelty:  0.00051767

p_int:  0.998597526

p_ni:  0.001088529

p_wrong:  0.000313944

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		57.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1		57.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
mean corpuscular hemoglobin concentration

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	chromosome 18 C18orf21 homolog	VGNC:5143	735721
Macaque	chromosome 18 open reading frame, human C18orf21		715440
Mouse	RIKEN cDNA 2700062C07 gene	MGI:1915296	68046
Rat	similar to RIKEN cDNA 2700062C07	RGD:1564673	498830
Dog	chromosome 7 C18orf21 homolog	VGNC:52582	100856500

Species	Name	OMA	EggNOG	Inparanoid
Chimp	chromosome 18 C18orf21 homolog
Macaque	chromosome 18 open reading frame, human C18orf21
Mouse	RIKEN cDNA 2700062C07 gene
Rat	similar to RIKEN cDNA 2700062C07
Dog	chromosome 7 C18orf21 homolog

Publication Statistics

PubMed Score 1.81

PubMed score by year

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PubTator Score 1.50

PubTator score by year

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Related Publications

Text Mined References (5)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title