Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

C12orf49

Ensembl ID

ENST00000261318
ENSP00000261318
ENSG00000111412

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0

biological term	0

cell line	0

cell type or tissue	0

cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.66 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 97 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.66 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 97 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (29)

Explore Interacting Targets

1 – 10 of 29

See Interactions on String-DB

PLSCR1

Tbio

Family: Enzyme

Novelty: 0.01483138

p_int: 0.999329688

p_ni: 0.000670302

p_wrong: 1.1e-8

Score: 0.165

Data Source: BioPlex,STRINGDB

ASPHD2

Tdark

Family: Enzyme

Novelty: 1.24088719

p_int: 0.998285652

p_ni: 0.001633704

p_wrong: 0.000080643

Data Source: BioPlex

HTRA1

Tchem

Family: Enzyme

Novelty: 0.0016879

p_int: 0.998195652

p_ni: 0.001650952

p_wrong: 0.000153397

Score: 0.173

Data Source: BioPlex,STRINGDB

KNTC1

Tbio

Novelty: 0.08083785

p_int: 0.995829205

p_ni: 0.004170795

Score: 0.186

Data Source: BioPlex,STRINGDB

ZWILCH

Tbio

Novelty: 0.05184569

p_int: 0.949745216

p_ni: 0.021140755

p_wrong: 0.029114029

Score: 0.243

Data Source: BioPlex,STRINGDB

LNPK

Tbio

Novelty: 0.07736762

p_int: 0.919106993

p_ni: 0.080893006

p_wrong: 1e-9

Data Source: BioPlex

SCCPDH

Tbio

Family: Enzyme

Novelty: 0.06603568

p_int: 0.904588113

p_ni: 0.095347859

p_wrong: 0.000064027

Data Source: BioPlex

ACP2

Tbio

Family: Enzyme

Novelty: 0.00355652

p_int: 0.893237964

p_ni: 0.106762036

Data Source: BioPlex

ARV1

Tbio

Novelty: 0.03235632

p_int: 0.883012203

p_ni: 0.116958642

p_wrong: 0.000029155

Data Source: BioPlex

CANX

Tbio

Novelty: 0.00087002

p_int: 0.881532978

p_ni: 0.118467022

Data Source: BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

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1 – 1 of 1

GO Term	Evidence	Assigned by
extracellular region	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (5)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		63.4

worry measurement	EFO_0009589	1	1	1		26.6

gut microbiome measurement	EFO_0007874	1	1	1		24.5

high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		21.5

neuroticism measurement	EFO_0007660	1	1	0	5.5	15.8

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
apolipoprotein A 1 measurement	EFO_0004614	1		63.4

worry measurement	EFO_0009589	1		26.6

gut microbiome measurement	EFO_0007874	1		24.5

high density lipoprotein cholesterol measurement	EFO_0004612	1		21.5

neuroticism measurement	EFO_0007660	0	5.5	15.8

Beta Count

Odds Ratio

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UniProt Keyword

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GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID
Chimp	chromosome 12 C12orf49 homolog	VGNC:5305	740605

Macaque	chromosome 11 open reading frame, human C12orf49		713916

Mouse	RIKEN cDNA 2410131K14 gene	MGI:1924042	76792

Rat	similar to hypothetical protein FLJ21415	RGD:1562310	498188

Dog	UPF0454 protein C12orf49 homolog		102153143

Species	Name	OMA	EggNOG	Inparanoid
Chimp	chromosome 12 C12orf49 homolog

Macaque	chromosome 11 open reading frame, human C12orf49

Mouse	RIKEN cDNA 2410131K14 gene

Rat	similar to hypothetical protein FLJ21415

Dog	UPF0454 protein C12orf49 homolog

Publication Statistics

PubMed Score 1.66

PubMed score by year

PubTator Score 0.43

PubTator score by year

Related Publications

Text Mined References (5)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Complete proteome

Glycoprotein

Polymorphism

Reference proteome

Secreted

Signal