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Tdark
C12orf49
UPF0454 protein C12orf49

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261318
  • ENSP00000261318
  • ENSG00000111412
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.66   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.66   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
PLSCR1
Tbio
Family:  Enzyme
Novelty:  0.01483138
p_int:  0.999329688
p_ni:  0.000670302
p_wrong:  1.1e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
ASPHD2
Tdark
Family:  Enzyme
Novelty:  1.24088719
p_int:  0.998285652
p_ni:  0.001633704
p_wrong:  0.000080643
Data Source:  BioPlex
HTRA1
Tchem
Family:  Enzyme
Novelty:  0.0016879
p_int:  0.998195652
p_ni:  0.001650952
p_wrong:  0.000153397
Score:  0.173
Data Source:  BioPlex,STRINGDB
KNTC1
Tbio
Novelty:  0.08083785
p_int:  0.995829205
p_ni:  0.004170795
Score:  0.186
Data Source:  BioPlex,STRINGDB
ZWILCH
Tbio
Novelty:  0.05184569
p_int:  0.949745216
p_ni:  0.021140755
p_wrong:  0.029114029
Score:  0.243
Data Source:  BioPlex,STRINGDB
LNPK
Tbio
Novelty:  0.07736762
p_int:  0.919106993
p_ni:  0.080893006
p_wrong:  1e-9
Data Source:  BioPlex
SCCPDH
Tbio
Family:  Enzyme
Novelty:  0.06603568
p_int:  0.904588113
p_ni:  0.095347859
p_wrong:  0.000064027
Data Source:  BioPlex
ACP2
Tbio
Family:  Enzyme
Novelty:  0.00355652
p_int:  0.893237964
p_ni:  0.106762036
Data Source:  BioPlex
ARV1
Tbio
Novelty:  0.03235632
p_int:  0.883012203
p_ni:  0.116958642
p_wrong:  0.000029155
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.881532978
p_ni:  0.118467022
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
63.4
worry measurement
1
1
1
26.6
gut microbiome measurement
1
1
1
24.5
high density lipoprotein cholesterol measurement
1
1
1
21.5
neuroticism measurement
1
1
0
5.5
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
63.4
worry measurement
1
26.6
gut microbiome measurement
1
24.5
high density lipoprotein cholesterol measurement
1
21.5
neuroticism measurement
0
5.5
15.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromosome 12 C12orf49 homolog
VGNC:5305
740605
Macaque
chromosome 11 open reading frame, human C12orf49
713916
Mouse
MGI:1924042
76792
Rat
RGD:1562310
498188
Dog
UPF0454 protein C12orf49 homolog
102153143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromosome 12 C12orf49 homolog
Macaque
chromosome 11 open reading frame, human C12orf49
Mouse
Rat
Dog
UPF0454 protein C12orf49 homolog
Publication Statistics
PubMed Score 1.66
PubMed score by year
PubTator Score 0.43
PubTator score by year
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Related Publications
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PMID
Year
Title