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Tdark
C12orf4
Protein C12orf4

Protein Summary
Description
Plays a role in mast cell degranulation. This gene is highly conserved from nematodes to humans. In rat, the orthologous gene encodes a cytoplasmic protein that is involved in mast cell degranulation. The human gene has been implicated in autosomal recessive intellectual disability. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261250
  • ENSP00000261250
  • ENSG00000047621
  • ENST00000545746
  • ENSP00000439996
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
IL6R
Tclin
Novelty:  0.00185005
p_int:  0.999999367
p_ni:  1.06e-7
p_wrong:  5.27e-7
Score:  0.282
Data Source:  BioPlex,STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.992783796
p_ni:  8e-9
p_wrong:  0.007216196
Score:  0.188
Data Source:  BioPlex,STRINGDB
ITFG2
Tbio
Novelty:  0.41720651
Score:  0.736
Data Source:  STRINGDB
TBCK
Tbio
Family:  Kinase
Novelty:  0.08568145
Score:  0.655
Data Source:  STRINGDB
PRICKLE1
Tbio
Novelty:  0.03175916
Score:  0.623
Data Source:  STRINGDB
TMEM106C
Tdark
Novelty:  0.34321342
Score:  0.619
Data Source:  STRINGDB
CPNE8
Tbio
Novelty:  0.14023162
Score:  0.61
Data Source:  STRINGDB
FAM160A2
Tbio
Novelty:  1.08224895
Score:  0.61
Data Source:  STRINGDB
RMC1
Tbio
Novelty:  0.02804116
Score:  0.608
Data Source:  STRINGDB
WDR93
Tdark
Novelty:  4.56619985
Score:  0.588
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
1
1
7.5
81.5
phosphorus measurement
2
2
2
74.1
2
2
0
1.1
71.2
glomerular filtration rate
2
2
2
42
calcium measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
7.5
81.5
phosphorus measurement
2
74.1
0
1.1
71.2
glomerular filtration rate
2
42
calcium measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromosome 12 C12orf4 homolog
VGNC:4953
451764
Macaque
chromosome 11 open reading frame, human C12orf4
710836
Mouse
MGI:107893
28040
Rat
RGD:1311164
297607
Dog
chromosome 27 C12orf4 homolog
VGNC:49229
477721
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromosome 12 C12orf4 homolog
Macaque
chromosome 11 open reading frame, human C12orf4
Mouse
Rat
Dog
chromosome 27 C12orf4 homolog
Publication Statistics
PubMed Score 3.43
PubMed score by year
PubTator Score 1.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title