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Tbio
C11orf74
Uncharacterized protein C11orf74

Protein Summary
Description
This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334307
  • ENSP00000334848
  • ENSG00000166352
  • ENST00000347206
  • ENSP00000299442
  • ENST00000446510
  • ENSP00000403937
  • ENST00000532470
  • ENSP00000431374
  • ENST00000534635
  • ENSP00000433152
  • ENST00000617650
  • ENSP00000483671

Symbol
  • NWC
  • HEPIS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.47   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.47   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
IFT43
Tbio
Novelty:  0.00478274
p_int:  0.99999993
p_ni:  7e-8
Score:  0.896
Data Source:  BioPlex,STRINGDB
WDR35
Tbio
Novelty:  0.02958717
p_int:  0.99999973
p_ni:  1.56e-7
p_wrong:  1.15e-7
Score:  0.863
Data Source:  BioPlex,STRINGDB
WDR19
Tbio
Novelty:  0.037197
p_int:  0.999997434
p_ni:  0.000002566
Score:  0.895
Data Source:  BioPlex,STRINGDB
IFT140
Tbio
Novelty:  0.02872897
p_int:  0.999991599
p_ni:  0.000008399
p_wrong:  2e-9
Score:  0.86
Data Source:  BioPlex,STRINGDB
IFT122
Tbio
Novelty:  0.02235986
p_int:  0.999984391
p_ni:  0.000015609
Score:  0.884
Data Source:  BioPlex,STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.840408338
p_ni:  0.159591662
Score:  0.158
Data Source:  BioPlex,STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
p_int:  0.824965791
p_ni:  0.175034209
Score:  0.29
Data Source:  BioPlex,STRINGDB
ZNF397
Tbio
Family:  TF
Novelty:  0.60034816
Score:  0.607
Data Source:  STRINGDB
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
Score:  0.554
Data Source:  STRINGDB
DUPD1
Tbio
Family:  Enzyme
Novelty:  0.2115789
Score:  0.55
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromosome 11 C11orf74 homolog
VGNC:3187
740210
Macaque
chromosome 14 C11orf74 homolog
716798
Mouse
MGI:1915420
68170
Rat
RGD:1309730
295952
Dog
chromosome 18 C11orf74 homolog
VGNC:51850
475941
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromosome 11 C11orf74 homolog
Macaque
chromosome 14 C11orf74 homolog
Mouse
Rat
Dog
chromosome 18 C11orf74 homolog
Publication Statistics
PubMed Score 6.47
PubMed score by year
PubTator Score 1.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title