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Tbio
BUD31
Protein BUD31 homolog

Protein Summary
Description
Involved in the pre-mRNA splicing process (PubMed:28502770, PubMed:28076346). May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity (PubMed:25091737).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222969
  • ENSP00000222969
  • ENSG00000106245
  • ENST00000403633
  • ENSP00000386023

Symbol
  • EDG2
  • G10
  • EDG2
  • Cwc14
  • EDG-2
  • fSAP17
  • YCR063W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.87
transcription factor binding site profile
0.76
virus perturbation
0.76
co-expressed gene
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.77   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.77   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (290)
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
p_int:  0.999844823
p_ni:  0.000155177
Score:  0.729
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.998404869
p_ni:  0.00159479
p_wrong:  3.41e-7
Score:  0.534
Data Source:  BioPlex,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.99776396
p_ni:  0.002235971
p_wrong:  6.9e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.997409332
p_ni:  0.002363974
p_wrong:  0.000226694
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.994422273
p_ni:  0.005577647
p_wrong:  7.9e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
KIAA1143
Tdark
Novelty:  3.96985921
p_int:  0.989546909
p_ni:  0.010451806
p_wrong:  0.000001285
Score:  0.542
Data Source:  BioPlex,STRINGDB
SYF2
Tbio
Novelty:  0.06114903
p_int:  0.98867483
p_ni:  0.011323944
p_wrong:  0.000001225
Score:  0.998
Data Source:  BioPlex,STRINGDB
PPIE
Tbio
Family:  Enzyme
Novelty:  0.01586411
p_int:  0.97272502
p_ni:  0.027274976
p_wrong:  4e-9
Score:  0.984
Data Source:  BioPlex,STRINGDB
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.950136636
p_ni:  0.049863363
p_wrong:  1e-9
Score:  0.756
Data Source:  BioPlex,STRINGDB
AKIRIN2
Tbio
Novelty:  0.04603317
p_int:  0.948155422
p_ni:  0.051830565
p_wrong:  0.000014013
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
3
3
93
dehydroepiandrosterone sulphate measurement
1
4
8
88.6
hormone measurement
2
2
3
78.7
reticulocyte count
2
1
2
78.5
lymphocyte count
1
1
1
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
3
93
dehydroepiandrosterone sulphate measurement
8
88.6
hormone measurement
3
78.7
reticulocyte count
2
78.5
lymphocyte count
1
75.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BUD31 homolog
VGNC:4280
736713
Macaque
BUD31 homolog
718694
Mouse
MGI:2141291
231889
Rat
RGD:621103
89819
Dog
BUD31 homolog
479743
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BUD31 homolog
Macaque
BUD31 homolog
Mouse
Rat
Dog
BUD31 homolog
Publication Statistics
PubMed Score 9.77
PubMed score by year
PubTator Score 61.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title