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Tdark
BTNL8
Butyrophilin-like protein 8

Protein Summary
Description
May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231229
  • ENSP00000231229
  • ENSG00000113303
  • ENST00000340184
  • ENSP00000342197
  • ENST00000400707
  • ENSP00000383543
  • ENST00000508408
  • ENSP00000424585
  • ENST00000511704
  • ENSP00000425207
  • ENST00000533815
  • ENSP00000435098
  • ENST00000610640
  • ENSP00000483717

Symbol
  • BTN9.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
tissue sample
0.67
cell type or tissue
0.56
cell line
0.52
phenotype
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.56   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.56   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
ITGA2
Tbio
Novelty:  0.0013482
p_int:  0.999993751
p_ni:  0.000006249
Data Source:  BioPlex
OSBP2
Tbio
Novelty:  0.02589566
p_int:  0.9998457
p_ni:  0.000002492
p_wrong:  0.000151808
Score:  0.189
Data Source:  BioPlex,STRINGDB
TMEM231
Tbio
Novelty:  0.17100188
p_int:  0.999814003
p_ni:  0.000185996
Score:  0.51
Data Source:  BioPlex,STRINGDB
GLRB
Tclin
Family:  IC
Novelty:  0.01721113
p_int:  0.999810777
p_ni:  0.000189141
p_wrong:  8.3e-8
Score:  0.197
Data Source:  BioPlex,STRINGDB
LNPEP
Tchem
Family:  Enzyme
Novelty:  0.00249049
p_int:  0.999638298
p_ni:  0.000361702
Data Source:  BioPlex
CNNM1
Tdark
Novelty:  0.11053515
p_int:  0.999515998
p_ni:  0.000483758
p_wrong:  2.44e-7
Score:  0.15
Data Source:  BioPlex,STRINGDB
LEPR
Tclin
Novelty:  0.00070587
p_int:  0.999476416
p_ni:  0.000227879
p_wrong:  0.000295705
Score:  0.197
Data Source:  BioPlex,STRINGDB
SCARB1
Tchem
Novelty:  0.00087703
p_int:  0.998929543
p_ni:  0.001070457
Data Source:  BioPlex
ITGA6
Tbio
Novelty:  0.00217985
p_int:  0.998837263
p_ni:  0.001162735
p_wrong:  2e-9
Data Source:  BioPlex
ITGA8
Tbio
Novelty:  0.0220023
p_int:  0.998723122
p_ni:  0.001276877
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Butyrophilin (BTN) family interactions
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Butyrophilin (BTN) family interactions
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
62.1
high density lipoprotein cholesterol measurement
2
2
2
56.8
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
62.1
high density lipoprotein cholesterol measurement
2
56.8
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
butyrophilin like 8
VGNC:6385
741207
Species
Name
OMA
EggNOG
Inparanoid
Chimp
butyrophilin like 8
Publication Statistics
PubMed Score 3.56
PubMed score by year
PubTator Score 2.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title