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Tbio
BTN3A2
Butyrophilin subfamily 3 member A2

Protein Summary
Description
Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells. This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356386
  • ENSP00000348751
  • ENSG00000186470
  • ENST00000377708
  • ENSP00000366937
  • ENST00000396934
  • ENSP00000380140
  • ENST00000396948
  • ENSP00000380152
  • ENST00000508906
  • ENSP00000442687
  • ENST00000527422
  • ENSP00000432138

Symbol
  • BT3.2
  • BTF3
  • BTF4
  • BTF4
  • BT3.2
  • CD277
  • BTN3.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.74
histone modification site profile
0.72
PubMedID
0.62
tissue sample
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.3   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.3   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (12)
BTN3A3
Tbio
Novelty:  0.1953685
p_int:  1
Score:  0.847
Data Source:  BioPlex,STRINGDB
BTN3A1
Tchem
Novelty:  0.02572232
p_int:  0.999999242
p_ni:  3.4e-7
p_wrong:  4.19e-7
Score:  0.928
Data Source:  BioPlex,STRINGDB
PEX13
Tbio
Novelty:  0.01777214
p_int:  0.998672596
p_ni:  0.000197934
p_wrong:  0.00112947
Score:  0.513
Data Source:  BioPlex,STRINGDB
ATP5MC1
Tbio
Family:  Enzyme
Novelty:  0.03538978
p_int:  0.993855223
p_ni:  0.006144769
p_wrong:  8e-9
Score:  0.267
Data Source:  BioPlex,STRINGDB
TMEM245
Tdark
Novelty:  0.30094854
p_int:  0.961124633
p_ni:  0.005062339
p_wrong:  0.033813027
Score:  0.239
Data Source:  BioPlex,STRINGDB
CCDC68
Tbio
Novelty:  0.1262502
p_int:  0.930517151
p_ni:  0.069482694
p_wrong:  1.55e-7
Score:  0.239
Data Source:  BioPlex,STRINGDB
IPP
Tbio
Novelty:  0.12841634
Score:  0.781
Data Source:  STRINGDB
PPL
Tbio
Novelty:  0.00684645
Score:  0.56
Data Source:  STRINGDB
C16orf90
Tdark
Novelty:  9.96116505
Score:  0.443
Data Source:  STRINGDB
METTL27
Tdark
Novelty:  0.34658724
Score:  0.414
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Butyrophilin (BTN) family interactions
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Butyrophilin (BTN) family interactions
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
12
12
97.1
3
8
0
1.2
94.4
BMI-adjusted waist circumference
3
7
11
93
1
6
0
1.1
92.6
self reported educational attainment
5
5
5
91.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
12
97.1
0
1.2
94.4
BMI-adjusted waist circumference
11
93
0
1.1
92.6
self reported educational attainment
5
91.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 16.30
PubMed score by year
PubTator Score 17.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title