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Tbio
BTN1A1
Butyrophilin subfamily 1 member A1

Protein Summary
Description
May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244513
  • ENSP00000244513
  • ENSG00000124557

Symbol
  • BTN
  • BT
  • BTN
  • BTN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
cell type or tissue
0.72
virus perturbation
0.59
PubMedID
0.58
microRNA
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.11   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.11   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
XDH
Tclin
Family:  Enzyme
Novelty:  0.00054185
Score:  0.975
Data Source:  Reactome,STRINGDB
PPL
Tbio
Novelty:  0.00684645
Score:  0.946
Data Source:  Reactome,STRINGDB
PRDM5
Tbio
Family:  TF; Epigenetic
Novelty:  0.01689997
Score:  0.572
Data Source:  STRINGDB
PLIN2
Tbio
Novelty:  0.0020792
Score:  0.554
Data Source:  STRINGDB
MOSPD2
Tbio
Novelty:  0.14602473
Score:  0.524
Data Source:  STRINGDB
CSN2
Tbio
Family:  Enzyme
Novelty:  0.00050291
Score:  0.514
Data Source:  STRINGDB
FLNB
Tbio
Novelty:  0.00568768
Score:  0.509
Data Source:  STRINGDB
GPAT4
Tbio
Family:  Enzyme
Novelty:  0.03409111
Score:  0.502
Data Source:  STRINGDB
IPP
Tbio
Novelty:  0.12841634
Score:  0.493
Data Source:  STRINGDB
FABP3
Tchem
Novelty:  0.00142249
Score:  0.488
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Butyrophilin (BTN) family interactions
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Butyrophilin (BTN) family interactions
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
5
0
1.2
93.2
intelligence
3
12
8
6.4
89.1
self reported educational attainment
3
3
3
88.7
1
3
0
1.1
88.7
liver iron measurement
1
1
1
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
93.2
intelligence
8
6.4
89.1
self reported educational attainment
3
88.7
0
1.1
88.7
liver iron measurement
1
82.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
butyrophilin subfamily 1 member A1
VGNC:7164
471892
Macaque
butyrophilin subfamily 1 member A1
700608
Mouse
MGI:103118
12231
Rat
RGD:1306984
306956
Dog
butyrophilin subfamily 1 member A1
VGNC:38562
100855656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
butyrophilin subfamily 1 member A1
Macaque
butyrophilin subfamily 1 member A1
Mouse
Rat
Dog
butyrophilin subfamily 1 member A1
Publication Statistics
PubMed Score 154.11
PubMed score by year
PubTator Score 33.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title